Estudo de compostos bioactivos e actividades biológicas do alecrim (Rosmarinus officinalis L.)
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Data
2015
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Resumo
As plantas constituem um recurso terapêutico ainda hoje muito utilizado. O interesse
mundial no uso das plantas medicinais tem sido crescente, com os seus efeitos benéficos a serem
redescobertos para o desenvolvimento de novos medicamentos.
Pela primeira vez, com esta dissertação, foi elaborada uma revisão bibliográfica
sistemática com o objectivo de clarificar o estado actual dos estudos sobre Rosmarinus
officinalis L., elucidando quais os seus compostos e as actividades biológicas mais relevantes.
Para tal, foi feita uma pesquisa na base de dados ‘PUBMED’, com os termos
“rosemary” e “Rosmarinus officinalis”, donde foram recolhidos 232 artigos publicados entre
1990 e 30 de Novembro de 2014 sobre as actividades farmacológicas e os compostos isolados
do alecrim.
Ao longo dos anos verificou-se um crescente interesse nas propriedades desta planta.
O ácido carnósico, o óleo essencial, o carnosol e o ácido rosmarínico foram os compostos mais
estudados, e as actividades anti-tumoral, anti-infecciosa e antioxidante as mais reportadas.
Pela consistência de estudos, o ácido carnósico e o óleo essencial de R. officinalis,
demonstram ser alternativas prometedoras para o desenvolvimento de novos fármacos antitumorais
e anti-infecciosos, respectivamente. Com esta revisão, conclui-se que o alecrim
constitui uma excelente fonte de compostos com inúmeras propriedades medicinais.
Plants are a therapeutic resource still widely used nowadays. The worldwide interest in the use of medicinal plants has been growing, with its beneficial effects being rediscovered for the development of new drugs. For the first time, with this work, it´s presented a systematic literature review in order to clarify the current state of research on Rosmarinus officinalis L., elucidating which compounds and biological activities are the most relevant. To this end, a search was made in the database PUBMED, with the terms "rosemary" and "Rosmarinus officinalis", which included 232 articles published between 1990 and November 30, 2014 about rosemary’s pharmacological activities and their isolated compounds. Over the years there has been an increasing interest in the properties of this plant. The carnosic acid, essential oil, carnosol, and rosmarinic acid were the most studied compounds and antitumoral, anti-infective and antioxidante the most activities reported. By the consistency of studies, carnosic acid and R. officinalis essential oil, shown to be promising alternatives for the development of new anti-tumoral and anti-infective drugs, respectively. With this review, we conclude that rosemary is an excellent source of compounds with numerous medicinal properties.
Plants are a therapeutic resource still widely used nowadays. The worldwide interest in the use of medicinal plants has been growing, with its beneficial effects being rediscovered for the development of new drugs. For the first time, with this work, it´s presented a systematic literature review in order to clarify the current state of research on Rosmarinus officinalis L., elucidating which compounds and biological activities are the most relevant. To this end, a search was made in the database PUBMED, with the terms "rosemary" and "Rosmarinus officinalis", which included 232 articles published between 1990 and November 30, 2014 about rosemary’s pharmacological activities and their isolated compounds. Over the years there has been an increasing interest in the properties of this plant. The carnosic acid, essential oil, carnosol, and rosmarinic acid were the most studied compounds and antitumoral, anti-infective and antioxidante the most activities reported. By the consistency of studies, carnosic acid and R. officinalis essential oil, shown to be promising alternatives for the development of new anti-tumoral and anti-infective drugs, respectively. With this review, we conclude that rosemary is an excellent source of compounds with numerous medicinal properties.
Descrição
Orientação: Patrícia Rijo
Palavras-chave
FARMACOLOGIA, MESTRADO INTEGRADO EM CIÊNCIAS FARMACÊUTICAS, MEDICAMENTOS, PLANTAS MEDICINAIS, ALECRIM, REVISÃO BIBLIOGRÁFICA, ÁCIDO CARNÓSICO, ÓLEOS ESSENCIAIS, PHARMACOLOGY, DRUGS, MEDICINAL PLANTS, ROSEMARY, BIBLIOGRAPHIC REVIEW, CARNOSIC ACID, ESSENTIAL OILS, CIÊNCIAS FARMACÊUTICAS, PHARMACEUTICAL SCIENCES