Toxigenómica na avaliação de compostos químicos
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Data
2006
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Edições Universitárias Lusófonas
Resumo
Apesar do facto de vivermos mergulhados num ambiente cheio dos mais diversos produtos químicos pouca informação existe sobre a sua toxicidade em relação aos seres humanos e outros seres vivos. Por tal motivo as autoridades reguladoras vêm expressando a sua preocupação e planeiam aprovar novos regulamentos para a avaliação da toxicidade de vários milhares de produtos químicos
de uso comum. Neste contexto tal envolverá estudos em larga escala de avaliação da toxicidade desses produtos. Com a informação reunida em bases de dados específicas e públicas espera-se obter uma melhor compreensão da sua importância para a saúde humana e para o ambiente. Tal facto ajudará
a tomada de medidas preventivas na defesa da saúde humana e ambiental. Contudo os métodos convencionais de avaliação da toxicidade têm várias limitações que impedem ou dificultam a efectivação de estudos em larga escala como pretendido. Neste contexto a toxigenómica é uma ciência nova que pode contribuir para obviar as limitações dos métodos convencionais e nessa medida dar uma importante contribuição para o melhor conhecimento da segurança dos produtos químicos.
Notwithstanding the fact that we live immersed in an environment filled with a great variety of chemicals, the information about their safety to human beings and other living organisms is scarce. Therefore, the regulatory bodies have lately expressed their concern and are planning new regulations for the toxicity evaluation of several thousands of commonly used chemicals. Accordingly, this will involve the review of the safety of chemicals in large-scale studies with the application of conventional toxicity test protocols. With this information gathered in specific and public databases, it is hoped that we obtain a better understanding of their relevance for human health as well as for a sustainable environmental development. This will help in establishing preventive policies in defence of human health and the environment. However, the conventional methods of toxicity evaluation have several drawbacks to allow for the intended large-scale studies. In this context, toxigenomics is emerging as a science that might help to circumvent the limitations of conventional methods and therefore give a useful contribution to a better understanding of the mechanisms of action of chemicals at a biomolecular level and in this way enable toxicologists to foster the predictive aspects of toxicology.
Notwithstanding the fact that we live immersed in an environment filled with a great variety of chemicals, the information about their safety to human beings and other living organisms is scarce. Therefore, the regulatory bodies have lately expressed their concern and are planning new regulations for the toxicity evaluation of several thousands of commonly used chemicals. Accordingly, this will involve the review of the safety of chemicals in large-scale studies with the application of conventional toxicity test protocols. With this information gathered in specific and public databases, it is hoped that we obtain a better understanding of their relevance for human health as well as for a sustainable environmental development. This will help in establishing preventive policies in defence of human health and the environment. However, the conventional methods of toxicity evaluation have several drawbacks to allow for the intended large-scale studies. In this context, toxigenomics is emerging as a science that might help to circumvent the limitations of conventional methods and therefore give a useful contribution to a better understanding of the mechanisms of action of chemicals at a biomolecular level and in this way enable toxicologists to foster the predictive aspects of toxicology.
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Revista Lusófona de Ciências e Tecnologias da Saúde
Palavras-chave
CIÊNCIAS FARMACÊUTICAS, FARMACOLOGIA, TOXICOLOGIA GENÉTICA, TOXICIDADE, MEIO AMBIENTE, PRODUTOS QUÍMICOS, PHARMACEUTICAL SCIENCES, PHARMACOLOGY, GENETIC TOXICOLOGY, TOXICITY, ENVIRONMENT, CHEMICAL PRODUCTS, MEDICINA, MEDICINE