Avaliação da eficácia de um creme contendo ureia na função de barreira cutânea
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Data
2008
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Edições Universitárias Lusófonas
Resumo
Os modelos in vivo de estudo da lesão cutânea com Lauril Sulfato de Sódio (LSS), são amplamente utilizados para avaliar a barreira cutânea e para a determinação da eficácia dos cremes que visam melhorar esta propriedade. O objectivo deste trabalho foi aplicar este modelo no estudo do impacto da aplicação de um creme contendo ureia.
14 voluntárias saudáveis aplicaram uma formulação durante 15 dias, 2x por dia num site randomizado da perna.
Aplicou-se, sob oclusão, LSS a 2,5% durante 24h no site tratado e noutro não tratado. Fez-se adicionalmente
oclusão num site não tratado, o controlo. Mediram-se os parâmetros Perda Transepidermica de Água (PTEA),
eritema, hidratação superficial e profunda nestes sites e num site que proporciona as variáveis basais.
Os resultados obtidos indicam que a aplicação da formulação provoca alterações positivas na barreira cutânea.
Estas são particularmente evidenciadas através das medições de PTEA, sendo menos evidentes nas outras
variáveis medidas. O estudo evidencia influência positiva do hidratante na função de protecção da barreira
cutânea, protegendo a pele do contacto com uma substância irritante.
In vivo models using sodium lauryl sulphate (SLS) to study cutaneous lesion are widely employed in the assessment of skin barrier function and to establish the efficacy of formulations that aim to improve it. The main purpose of this work was to apply such a model to investigate the impact of treating the skin with a cream containing urea. Fourteen healthy volunteers participated in this study and were instructed to apply a formulation for 2 weeks, twice daily, to a randomized site in the lower leg. A 2.5% aqueous solution of SLS was applied under occlusion to an untreated site and to the site treated with cream. The adhesive patch used to apply the SLS solution was applied to a third site. Fifteen minutes after removal of the adhesives transepidermal water loss, erythema, superficial and deep hydration were measured in all sites. The results obtained in the study indicate that skin treatment for 2 weeks with the cream causes a significant improvement in the cutaneous barrier. This effect is especially evident in theTEWLdata. The current work indicates that the moisturizer has the capacity to influence positively the cutaneous barrier function, and protect the skin from the contact with an irritant.
In vivo models using sodium lauryl sulphate (SLS) to study cutaneous lesion are widely employed in the assessment of skin barrier function and to establish the efficacy of formulations that aim to improve it. The main purpose of this work was to apply such a model to investigate the impact of treating the skin with a cream containing urea. Fourteen healthy volunteers participated in this study and were instructed to apply a formulation for 2 weeks, twice daily, to a randomized site in the lower leg. A 2.5% aqueous solution of SLS was applied under occlusion to an untreated site and to the site treated with cream. The adhesive patch used to apply the SLS solution was applied to a third site. Fifteen minutes after removal of the adhesives transepidermal water loss, erythema, superficial and deep hydration were measured in all sites. The results obtained in the study indicate that skin treatment for 2 weeks with the cream causes a significant improvement in the cutaneous barrier. This effect is especially evident in theTEWLdata. The current work indicates that the moisturizer has the capacity to influence positively the cutaneous barrier function, and protect the skin from the contact with an irritant.
Descrição
Revista Lusófona de Ciências e Tecnologias da Saúde
Palavras-chave
CIÊNCIAS FARMACÊUTICAS, PHARMACEUTICAL SCIENCES, PRODUTOS FARMACÊUTICOS, PHARMACEUTICAL PRODUCTS, DERMATOLOGIA, DERMATOLOGY, ESTUDOS DE CASO, CASE STUDIES, HIDRATAÇÃO, HYDRATION, LAURIL SULFATO DE SÓDIO, SODIUM LAURYL SULPHATE, BARREIRA CUTÂNEA, SKIN BARRIER, UREIA, UREA