Enlarged PLIN5-uncoated lipid droplets in inner regions of skeletal muscle type II fibers associate with type 2 diabetes

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dc.contributor.authorFachada,Vasco
dc.contributor.authorRahkila,Paavo
dc.contributor.authorFachada,Nuno
dc.contributor.authorTurpeinen,Tuomas
dc.contributor.authorKujala,Urho M.
dc.contributor.authorKainulainen,Heikki
dc.contributor.institutionFaculdade de Engenharia
dc.date.issued2022-02
dc.descriptionActa Histochemica 124 (2022)
dc.description.abstractSkeletal muscle physiology remains of paramount importance in understanding insulin resistance. Due to its high lipid turnover rates, regulation of intramyocellular lipid droplets (LDs) is a key factor. Perilipin 5 (PLIN5) is one of the most critical agents in such regulation, being often referred as a protector against lipotoxicity and consequent skeletal muscle insulin resistance. We examined area fraction, size, subcellular localization and PLIN5 association of LDs in two fiber types of type 2 diabetic (T2D), obese (OB) and healthy (HC) individuals by means of fluorescence microscopy and image analysis. We found that T2D type II fibers have a significant sub-population of large and internalized LDs, uncoated by PLIN5. Based on this novel result, additional hypotheses for the pathophysiology of skeletal muscle insulin resistance are formulated, together with future research directions. Keywords: Lipid droplets, PLIN5, Type II diabetes, Skeletal muscle, Insulin resistance, Fiber typept
dc.description.statusNon peer reviewed
dc.formatapplication/pdf
dc.identifier.citationFachada , V , Rahkila , P , Fachada , N , Turpeinen , T , Kujala , U M & Kainulainen , H 2022 , ' Enlarged PLIN5-uncoated lipid droplets in inner regions of skeletal muscle type II fibers associate with type 2 diabetes ' , Default journal .
dc.identifier.issn1646-3730
dc.language.isoeng
dc.publisherEdições Universitárias Lusófonas
dc.relation.ispartofDefault journal
dc.rightsopenAccess
dc.subjectBIOLOGIA
dc.subjectLÍPIDOS
dc.subjectDIABETES TIPO 2
dc.subjectMÚSCULOS ESQUELÉTICOS
dc.subjectRESISTÊNCIA À INSULINA
dc.subjectBIOLOGY
dc.subjectLIPIDS
dc.subjectTYPE 2 DIABETES
dc.subjectSKELETAL MUSCLE
dc.subjectINSULIN RESISTANCE
dc.titleEnlarged PLIN5-uncoated lipid droplets in inner regions of skeletal muscle type II fibers associate with type 2 diabetesen

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