Mycobacterium vaccae adaptation to disinfectants and hand sanitisers, and evaluation of cross-tolerance with antimicrobials

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dc.contributor.authorde Carvalho, Carla C.C.R.
dc.contributor.authorTeixeira, Raquel
dc.contributor.authorFernandes, Pedro
dc.contributor.institutionFE - Faculty of Engineering
dc.date.issued2020-09
dc.descriptionPublisher Copyright: © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
dc.description.abstractMycobacterium vaccae is being considered as an adjuvant to antituberculosis therapy, tested for the treatment of autoimmune diseases, and as an anti-depressive agent. This bacterium is ubiquitous in the environment and the widespread use of disinfectants and sanitisers may lead to its adaptation to these compounds. In the present study, M. vaccae cells adapted to these compounds mainly by making adjustments in their lipid composition and net surface charge. The modifications in the lipid composition led to changes in membrane permeability which resulted in increased tolerance towards levofloxacin, thioridazine, and omeprazole.en
dc.identifier.citationde Carvalho, C C C R, Teixeira, R & Fernandes, P 2020, 'Mycobacterium vaccae adaptation to disinfectants and hand sanitisers, and evaluation of cross-tolerance with antimicrobials', Antibiotics, vol. 9, no. 9, 544, pp. 1-16. https://doi.org/10.3390/antibiotics9090544
dc.identifier.doihttps://doi.org/10.3390/antibiotics9090544
dc.identifier.issn2079-6382
dc.identifier.urihttps://hdl.handle.net/10437/12143
dc.identifier.urlhttps://www.scopus.com/pages/publications/85093901603
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)
dc.relation.ispartofAntibiotics
dc.rightsopenAccess
dc.subjectBIOTECNOLOGIA
dc.subjectANTIBIÓTICOS
dc.subjectBACTÉRIAS
dc.subjectANTIMICROBIANOS
dc.subjectPERMEABILIDADE
dc.subjectBIOTECHNOLOGY
dc.subjectANTIBIOTICS
dc.subjectBACTERIA
dc.subjectANTIMICROBIAL
dc.subjectPERMEABILITY
dc.titleMycobacterium vaccae adaptation to disinfectants and hand sanitisers, and evaluation of cross-tolerance with antimicrobialsen
dc.typearticle

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