Mycobacterium vaccae adaptation to disinfectants and hand sanitisers, and evaluation of cross-tolerance with antimicrobials

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dc.contributor.authorCarvalho, Carla C. C. R. de
dc.contributor.authorTeixeira, Raquel
dc.contributor.authorFernandes, Pedro Carlos de Barros
dc.contributor.institutionFaculdade de Engenharia
dc.date.issued2020
dc.descriptionPublicação : Antibiotics
dc.description.abstractMycobacterium vaccae is being considered as an adjuvant to antituberculosis therapy, tested for the treatment of autoimmune diseases, and as an anti-depressive agent. This bacterium is ubiquitous in the environment and the widespread use of disinfectants and sanitisers may lead to its adaptation to these compounds. In the present study, M. vaccae cells adapted to these compounds mainly by making adjustments in their lipid composition and net surface charge. The modifications in the lipid composition led to changes in membrane permeability which resulted in increased tolerance towards levofloxacin, thioridazine, and omeprazole.en
dc.description.statusNon peer reviewed
dc.formatapplication/pdf
dc.identifier.citationCarvalho , C C C R D , Teixeira , R & Fernandes , P C D B 2020 , ' Mycobacterium vaccae adaptation to disinfectants and hand sanitisers, and evaluation of cross-tolerance with antimicrobials ' , Default journal .
dc.identifier.issn1646-3730
dc.language.isoeng
dc.publisherEdições Universitárias Lusófonas
dc.relation.ispartofDefault journal
dc.rightsopenAccess
dc.subjectBIOTECNOLOGIA
dc.subjectANTIBIÓTICOS
dc.subjectBACTÉRIAS
dc.subjectANTIMICROBIANOS
dc.subjectPERMEABILIDADE
dc.subjectBIOTECHNOLOGY
dc.subjectANTIBIOTICS
dc.subjectBACTERIA
dc.subjectANTIMICROBIAL
dc.subjectPERMEABILITY
dc.titleMycobacterium vaccae adaptation to disinfectants and hand sanitisers, and evaluation of cross-tolerance with antimicrobialsen
dc.typearticle

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