Mycobacterium vaccae adaptation to disinfectants and hand sanitisers, and evaluation of cross-tolerance with antimicrobials

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dc.contributor.authorCarvalho, Carla C. C. R. de
dc.contributor.authorTeixeira, Raquel
dc.contributor.authorFernandes, Pedro Carlos de Barros
dc.date.accessioned2021-09-06T10:23:17Z
dc.date.available2021-09-06T10:23:17Z
dc.date.issued2020
dc.descriptionPublicação : Antibioticspt
dc.description.abstractMycobacterium vaccae is being considered as an adjuvant to antituberculosis therapy, tested for the treatment of autoimmune diseases, and as an anti-depressive agent. This bacterium is ubiquitous in the environment and the widespread use of disinfectants and sanitisers may lead to its adaptation to these compounds. In the present study, M. vaccae cells adapted to these compounds mainly by making adjustments in their lipid composition and net surface charge. The modifications in the lipid composition led to changes in membrane permeability which resulted in increased tolerance towards levofloxacin, thioridazine, and omeprazole.en
dc.description.sponsorshipFundação para a Ciência e a Tecnologia, I.P. (FCT), Portugal, through project IF/01203/2013/CP1163/CT0002.pt
dc.formatapplication/pdf
dc.identifier.other10.3390/antibiotics9090544
dc.identifier.urihttp://hdl.handle.net/10437/12143
dc.language.isoengpt
dc.publisherMDPIpt
dc.rightsopenAccess
dc.subjectBIOTECNOLOGIApt
dc.subjectANTIBIÓTICOSpt
dc.subjectBACTÉRIASpt
dc.subjectANTIMICROBIANOSpt
dc.subjectPERMEABILIDADEpt
dc.subjectBIOTECHNOLOGYen
dc.subjectANTIBIOTICSen
dc.subjectBACTERIAen
dc.subjectANTIMICROBIALen
dc.subjectPERMEABILITYen
dc.titleMycobacterium vaccae adaptation to disinfectants and hand sanitisers, and evaluation of cross-tolerance with antimicrobialsen
dc.typearticlept

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