Assessing the impact of the regular use (4 weeks) of an alcohol-based hand sanitizer on TEWL and epidermal hydration
Miniatura indisponível
Ficheiros
Data
2015
Título da revista
ISSN da revista
Título do Volume
Editora
Edições Universitárias Lusófonas
Resumo
O estrato córneo é o principal protetor contra a agressão física, química, biológica e perda de água na pele humana. A lavagem repetida das mãos especialmente com desinfetantes à base de álcool pode resultar em secura e agressão. Este estudo tem como objetivo avaliar o impacto do uso regular de quatro semanas de duração de um gel desinfetante para as mãos à base de álcool sobre a hidratação da pele sobre a função de 'barreira' epidérmica usando um modelo cinético para quantificar as curvas de dessorção de PTEA na sequência de um teste POST. Um grupo de 13 mulheres (19,7 ± 1,0 anos de idade) lavaram as mãos durante 29 dias consecutivos com um desinfetante gel à base de etanol disponível no mercado. A PTEA, hidratação superficial (HS) e hidratação profunda (HP) foram medidas nos dias 1, 8, 15, 22 e 29, enquanto a PTEA foi registada continuamente na sequência de um POST de 24h nos dias 1, 15 e 29 numa segunda zona da pele . Não foram encontradas diferenças para a mão de controlo ao longo do estudo. Para a mão teste foi encontrado um aumento de PTEA entre os dias 1 e 8, bem como um aumento de SH e DH entre os dias 1 e 22. Nenhuma diferença significativa foi encontrada com os parâmetros cinéticos. Estes resultados sugerem que o uso frequente do gel desinfetante para as mãos pode alterar a função de barreira da pele.
The Stratum corneum is a principal protector against physical, chemical, biological aggression and water loss in human skin. The repeated use of alcohol-based hand sanitizers might result in dryness and aggression. This study aims to evaluate the impact of a four week-long regular use of an alcohol-based gel hand sanitizer on skin hydration on the epidermal ‘barrier’ function using a kinetic model to quantify TEWL desorption curves following a POST test. A group of 13 female (19.7 ± 1.0 years old) washed one of their hands for 29 consecutive days with a commercially available ethanol-based gel sanitizer. TEWL, superficial hydration (SH) and deep hydration (DH) were measured on days 1, 8, 15, 22 and 29, while a continuous TEWL recording following a 24 hour POST was made on days 1, 15 and 29 on a second skin area. No differences were found for the control hand throughout the study. For the test hand an increase of TEWL was found between days 1 and 8, as well as an increase of SH and DH between days 1 and 22. No significant differences were found for the kinetic parameters. These results suggest that the frequent use of the sanitizer gel might alter the skin barrier function.
The Stratum corneum is a principal protector against physical, chemical, biological aggression and water loss in human skin. The repeated use of alcohol-based hand sanitizers might result in dryness and aggression. This study aims to evaluate the impact of a four week-long regular use of an alcohol-based gel hand sanitizer on skin hydration on the epidermal ‘barrier’ function using a kinetic model to quantify TEWL desorption curves following a POST test. A group of 13 female (19.7 ± 1.0 years old) washed one of their hands for 29 consecutive days with a commercially available ethanol-based gel sanitizer. TEWL, superficial hydration (SH) and deep hydration (DH) were measured on days 1, 8, 15, 22 and 29, while a continuous TEWL recording following a 24 hour POST was made on days 1, 15 and 29 on a second skin area. No differences were found for the control hand throughout the study. For the test hand an increase of TEWL was found between days 1 and 8, as well as an increase of SH and DH between days 1 and 22. No significant differences were found for the kinetic parameters. These results suggest that the frequent use of the sanitizer gel might alter the skin barrier function.
Descrição
Palavras-chave
HIDRATAÇÃO, CIÊNCIAS FARMACÊUTICAS, PRODUTOS FARMACÊUTICOS, DESINFEÇÃO, ESTUDOS DE CASO, MÃOS, PERDA TRANSEPIDÉRMICA DE ÁGUA, PHARMACEUTICAL SCIENCES, PHARMACEUTICAL PRODUCTS, DISINFECTION, CASE STUDIES, HYDRATION, TRANSEPIDERMAL WATER LOSS, HANDS
Citação
Silva , H , Tavares , L , Faria , R , Delsin , S D & Rodrigues , L M 2015 , ' Assessing the impact of the regular use (4 weeks) of an alcohol-based hand sanitizer on TEWL and epidermal hydration ' , Default journal .