A função barreira na pele sensível das mãos : um estudo piloto por um método dinâmico
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Data
2009
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Editora
Edições Universitárias Lusófonas
Resumo
Estudos recentes sugerem que a chamada “pele sensível” afectará cerca de 50% da população nas sociedades
desenvolvidas, aspecto que não pode ser ignorado, apesar das conhecidas dificuldades em caracterizar esta condição,ou mesmo em justificar essa prevalência. O presente estudo piloto procurou explorar a integridade da barreira
cutânea em indivíduos com “pele sensível” nas mãos, através de um modelo compartimental previamente
desenvolvido, conhecido pelo seu rigor e sensibilidade.
Cinco voluntários do sexo feminino com indicação de pele sensível foram sujeitos a oclusão durante 24H ao nível
das mãos. Após a remoção da oclusão avaliou-se a Perda Trans Epidérmica de Água (PTEA) durante 30 min.
Aplicou-se um modelo bicompartimental aos dados de PTEA, calculando-se o parâmetro relativo à alteração da
barreira cutânea (t1/2 evap - tempo de semi-vida de evaporação). Os dados obtidos foram comparados com
resultados de referência já publicados.
Ot1/2 evap é superior nos indivíduos referidos como “pele sensível” comparado com indivíduos ditos normais. Esta
alteração na barreira parece justificar a sensação de secura cutânea característica da pele sensível, bem como uma maior susceptibilidade a factores exteriores, por aumento da penetração transcutânea de substâncias agressoras. Por
se tratar de um estudo-piloto, estes dados têm que ser confirmados com uma população mais alargada.
Recent studies suggest that sensitive skin affects about 50% of the population in developed societies. This aspect cannot be ignored in spite of the known difficulties in characterizing this condition or even in justifying that prevalence. The current pilot study attempted to explore cutaneous barrier integrity in individuals with “sensitive skin” on their hands, through the compartmental model previously developed which is known for its rigor and sensibility. Five female volunteers with signs of sensitive skin will submited to an occlusion procedure in the hand for a 24 hour period. After removal , we evaluated the Trans-Epidermal Water Loss (TEWL) during 30 minutes. Then a bicompartmental model of the TEWL data was applied and calculated the parameter describing cutaneous barrier alteration (t1/2 evap – half-life evaporation) calculated. The obtained data was compared with reference results that have already been published. The t1/2 evap is higher in the individuals referred to as having “sensitive skin” comparing to those considered as normal. This alteration in the barrier seems to justify the sensation of cutaneous dryness which is characteristic of sensitive skin, as well as a higher susceptibility to external factors due to the increase of the transcutaneous penetration of aggressive substances. Given that this is a pilot study, these data have to be confirmed with a wider population.
Recent studies suggest that sensitive skin affects about 50% of the population in developed societies. This aspect cannot be ignored in spite of the known difficulties in characterizing this condition or even in justifying that prevalence. The current pilot study attempted to explore cutaneous barrier integrity in individuals with “sensitive skin” on their hands, through the compartmental model previously developed which is known for its rigor and sensibility. Five female volunteers with signs of sensitive skin will submited to an occlusion procedure in the hand for a 24 hour period. After removal , we evaluated the Trans-Epidermal Water Loss (TEWL) during 30 minutes. Then a bicompartmental model of the TEWL data was applied and calculated the parameter describing cutaneous barrier alteration (t1/2 evap – half-life evaporation) calculated. The obtained data was compared with reference results that have already been published. The t1/2 evap is higher in the individuals referred to as having “sensitive skin” comparing to those considered as normal. This alteration in the barrier seems to justify the sensation of cutaneous dryness which is characteristic of sensitive skin, as well as a higher susceptibility to external factors due to the increase of the transcutaneous penetration of aggressive substances. Given that this is a pilot study, these data have to be confirmed with a wider population.
Descrição
Revista Lusófona de Ciências e Tecnologias da Saúde
Palavras-chave
MEDICINA, DERMATOLOGIA, MEDICINE, DERMATOLOGY, PELE, SKIN, ESTUDOS DE CASO, CASE STUDIES, BARREIRA CUTÂNEA, PERDA TRANSEPIDÉRMICA DE ÁGUA, MÃOS, SKIN BARRIER, TRANSEPIDERMAL WATER LOSS, HANDS