Multi-enzyme systems in flow chemistry

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dc.contributor.authorFernandes, Pedro
dc.contributor.authorde Carvalho, Carla C.C.R.
dc.contributor.institutionFaculdade de Engenharia
dc.date.issued2021
dc.descriptionPublisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
dc.description.abstractRecent years have witnessed a growing interest in the use of biocatalysts in flow reactors. This merging combines the high selectivity and mild operation conditions typical of biocatalysis with enhanced mass transfer and resource efficiency associated to flow chemistry. Additionally, it provides a sound environment to emulate Nature by mimicking metabolic pathways in living cells and to produce goods through the systematic organization of enzymes towards efficient cascade reactions. Moreover, by enabling the combination of enzymes from different hosts, this approach paves the way for novel pathways. The present review aims to present recent developments within the scope of flow chemistry involving multi-enzymatic cascade reactions. The types of reactors used are briefly addressed. Immobilization methodologies and strategies for the application of the immobilized biocatalysts are presented and discussed. Key aspects related to the use of whole cells in flow chemistry are presented. The combination of chemocatalysis and biocatalysis is also addressed and relevant aspects are highlighted. Challenges faced in the transition from microscale to industrial scale are presented and discusseden
dc.identifier.citationFernandes, P & de Carvalho, C C C R 2021, 'Multi-enzyme systems in flow chemistry', Processes, vol. 9, no. 2, 225, pp. 1-23. https://doi.org/10.3390/pr9020225
dc.identifier.doihttps://doi.org/10.3390/pr9020225
dc.identifier.issn2227-9717
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85100117395&partnerID=8YFLogxK
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)
dc.relation.ispartofProcesses
dc.rightsopenAccess
dc.subjectBIOTECNOLOGIA
dc.subjectBIOQUÍMICA
dc.subjectENZIMAS
dc.subjectMETABOLISMO CELULAR
dc.subjectREAÇÕES QUÍMICAS
dc.subjectBIOTHECNOLOGY
dc.subjectBIOCHEMISTRY
dc.subjectENZYMES
dc.subjectCELLULAR METABOLISM
dc.subjectCHEMICAL REACTIONS
dc.titleMulti-enzyme systems in flow chemistryen
dc.typereview

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