Acerca do impacto da oclusão na reparação in vivo da integridade cutânea
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Data
2013
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Edições Universitárias Lusófonas
Resumo
A grande diversidade de apósitos disponível para a recuperação da integridade cutânea torna complexa e difícil a sua escolha. Torna-se pois fundamental, aprofundar o conhecimento sobre o impacto específico dos diferentes materiais de penso. O presente estudo pretende ilustrar o impacto da oclusão na recuperação da função de “barreira” da pele e envolveu 8 mulheres saudáveis ( = 22,6±1,1) em cujos antebraços foram marcados 3 sítios experimentais sujeitos a biopsia superficial cutânea (BSC) com cianoacrilato, mantendo integro um quarto local, assim utilizado como controlo negativo (CN). Dois dos locais experimentais sujeitos a BSC foram aleatoriamente ocludidos com o apósito de hidroxipoliuretano (PermaFoam®, Hartmann)(sitio A) ou com parafilm (sitio B) e o terceiro local (sitio C) deixado sem oclusão, funcionando como controlo positivo (CP). As variáveis em estudo foram a Perda Transepidérmica de água (PTEA, Tewameter TM300), o eritrema (Minolta CR3000) e a microcirculação local (LDF Periflux). Os resultados sugerem uma mais rápida recuperação da integridade cutânea nos sítios ocludidos, quando comparados com o respectivo controle, salientando-se nestes, o local tratado com o apósito de hidroxipoliuretano. Conclui-se que, nas presentes condições experimentais, a oclusão determina uma maior e mais rápida recuperação da integridade cutânea in vivo.
The wide diversity of wound dressings available to recover skin integrity makes the selection a complex and difficult process. It is crucial to learn more about the specific impact of different wound dressings. The objective of the present study is to illustrate the impact of the occlusion on the recovery of the skin "barrier" function. Eight healthy women ( = 22,6±1,1) were chosen and three experimental sites marked on the ventral aspect of both forearms, in order to apply a skin surface biopsy (SSB) with cyanoacrylate. An additional site was not submitted to SSB and thus used as a negative control (NC). Two of the SSB sites were randomly occluded with hydroxypolyurethane (PermaFoam ®, Hartmann) (site A) or with parafilm (site B) and the third site (site C) was left without occlusion, acting as a positive control (PC). The variables studied were the Trans-epidermal water loss (TEWL, Tewameter TM300), the erythema (Minolta CR3000) and local microcirculation (LDF Periflux).Results suggest a faster recovery of skin integrity in all the occluded sites, particularly when using the hydroxypolyurethane wound dressing, compared with the control group. We conclude that, under these experimental conditions, occlusion determines a greater and faster recovery of skin integrity in vivo.
The wide diversity of wound dressings available to recover skin integrity makes the selection a complex and difficult process. It is crucial to learn more about the specific impact of different wound dressings. The objective of the present study is to illustrate the impact of the occlusion on the recovery of the skin "barrier" function. Eight healthy women ( = 22,6±1,1) were chosen and three experimental sites marked on the ventral aspect of both forearms, in order to apply a skin surface biopsy (SSB) with cyanoacrylate. An additional site was not submitted to SSB and thus used as a negative control (NC). Two of the SSB sites were randomly occluded with hydroxypolyurethane (PermaFoam ®, Hartmann) (site A) or with parafilm (site B) and the third site (site C) was left without occlusion, acting as a positive control (PC). The variables studied were the Trans-epidermal water loss (TEWL, Tewameter TM300), the erythema (Minolta CR3000) and local microcirculation (LDF Periflux).Results suggest a faster recovery of skin integrity in all the occluded sites, particularly when using the hydroxypolyurethane wound dressing, compared with the control group. We conclude that, under these experimental conditions, occlusion determines a greater and faster recovery of skin integrity in vivo.
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Palavras-chave
MEDICINA, PELE, BIÓPSIAS, CICATRIZAÇÃO, DISPOSITIVOS MÉDICOS, MEDICINE, SKIN, BIOPSIES, HEALING, MEDICAL DEVICES
Citação
Pereira , M M , Saraiva , J & Rodrigues , L M 2013 , ' Acerca do impacto da oclusão na reparação in vivo da integridade cutânea ' , Default journal .