Atividade antioxidante e potencial antidiabético de extratos de frutos da família Myrtaceae : efeito inibitório na atividade de a-amilase e a-glicosidase
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2021
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Existe uma grande diversidade de plantas que produzem pequenos frutos comestíveis na região da Mata Atlântica
do Brasil e que são utilizados, de modo empírico, para tratar várias doenças, como diabetes, devido aos frutos
coloridos serem fonte de antioxidantes fenólicos na dieta alimentar. Neste estudo investigamos a atividade
inibitória de extratos metanólicos de frutos da família Myrtaceae: Psidium cattleianum (araçá), Syzygium cumini
(jambolão), Campomanesia xanthocarpa (guabiroba), Eugenia uniflora (pitanga) e Eugenia pyriformis (uvaia)
na inibição da atividade das enzimas α-amilase e α-glicosidase intestinal (maltose e sacarose). A atividade
antioxidante foi determinada em dois diferentes ensaios in vitro: 2,2’-azinobis (3-etilbenztiazolina-6-sulfonato)
(ABTS) e 2,2’-difenil-1-picrilhidrazil (DPPH). Os extratos de P. cattleianum, S. cumini, E. pyriformis inibiram a
atividade da α-amilase entre 13% e 60% (P <0,05). O extrato de P. cattleianum inibiu a atividade da α-glicosidase
(substrato maltose ou sacarose) entre 15% e 61% (P <0,05). Além disso, esses frutos são ricos em compostos
fenólicos com atividade antioxidante.
Palavras-chave: Myrtaceae, diabetes, fenólicos, α-glicosidase, α-amilase
There is a great diversity of plants which are grown in the Atlantic Forest region of Brazil that produce small, colorful, edible fruit that are used in empiric mode to treat several diseases, such as diabetes, as fruits are a rich source of dietary phenolic antioxidants. In this study, we investigated the inhibitory activity of methanolic fruit extracts from the Myrtaceae family -Psidium cattleianum (araçá), Syzygium cumini (jambolão), Campomanesia xanthocarpa (guabiroba), Eugenia uniflora (pitanga) and Eugenia pyriformis (uvaia) - against α-amylase and intestinal α-glucosidase (maltose and sucrose). The antioxidant activities were evaluated using two different in vitro assays: the 2,2’-azinobis(3-ethylbenzthiazoline-6-sulphonate) (ABTS) test and the 2,2’-diphenyl-1-picrylhydrazyl (DPPH) test. The extracts of P. cattleianum, S. cumini, E. pyriformis inhibited α-amylase activity between 13% and 60% (p<0.05). The extracts of P. cattleianum also inhibited α-glucosidase activity with either maltose or sucrose as substrate between 15% and 61% (p<0.05). Additionally, these fruits are rich in phenolic compounds with antioxidant activities. Keywords: Myrtaceae, diabetes, phenolics, α-glucosidase, α-amylase
There is a great diversity of plants which are grown in the Atlantic Forest region of Brazil that produce small, colorful, edible fruit that are used in empiric mode to treat several diseases, such as diabetes, as fruits are a rich source of dietary phenolic antioxidants. In this study, we investigated the inhibitory activity of methanolic fruit extracts from the Myrtaceae family -Psidium cattleianum (araçá), Syzygium cumini (jambolão), Campomanesia xanthocarpa (guabiroba), Eugenia uniflora (pitanga) and Eugenia pyriformis (uvaia) - against α-amylase and intestinal α-glucosidase (maltose and sucrose). The antioxidant activities were evaluated using two different in vitro assays: the 2,2’-azinobis(3-ethylbenzthiazoline-6-sulphonate) (ABTS) test and the 2,2’-diphenyl-1-picrylhydrazyl (DPPH) test. The extracts of P. cattleianum, S. cumini, E. pyriformis inhibited α-amylase activity between 13% and 60% (p<0.05). The extracts of P. cattleianum also inhibited α-glucosidase activity with either maltose or sucrose as substrate between 15% and 61% (p<0.05). Additionally, these fruits are rich in phenolic compounds with antioxidant activities. Keywords: Myrtaceae, diabetes, phenolics, α-glucosidase, α-amylase
Descrição
Biomedical and biopharmaceutical research : jornal de investigação biomédica e biofarmacêutica
Palavras-chave
MEDICINA, BIOMEDICINA, ANTIOXIDANTES, PLANTAS MEDICINAIS, MEDICINE, BIOMEDICINE, ANTIOXIDANTS, MEDICINAL PLANTS