Estudo clínico piloto para avaliar a eficácia do extrato de oliva contendo hidroxitirosol para tratamento oral e tópico do melasma
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Data
2020
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Edições Universitárias Lusófonas
Resumo
O melasma é uma das hiperpigmentações adquiridas mais comuns e pode causar prejuízos na qualidade
de vida. Os tratamentos apresentam limitações e, portanto, tratamentos auxiliares para o controle do
melasma são de grande interesse. O objetivo do estudo foi avaliar a eficácia clínica de tratamentos oral e
tópico à base de extrato de oliva contendo hidroxitirosol para o controle do melasma. Foi realizado um
estudo clínico piloto com 42 mulheres com melasma randomizadas em três grupos com 14 participantes -
controle, oral ou tópico - que receberam tratamento diário com hidroxitirosol ou placebo por 90 dias. O
melasma foi avaliado mensalmente utilizando os índices de área e gravidade do melasma (mMASJ) e de
melanina e eritema. A análise estatística foi realizada usando ANOVA entre os grupos e ANOVA RM em
cada grupo individualmente. O indice de melanina e eritema e mMASI resultaram em valores menores para
o tratamento oral comparado com os grupos controle e tópico. No entanto, o tratamento oral reduziu
significati mente os valores do indice mMASI (p=0,0132) e melanina (p=0.047) após 60 dias. Por fim, os
tratamentos com extrato de oliva baseado em hidroxitirosol mostraram grande potencial para o controle
do melasma ou como adjuvante ao tratamento convencional.
Melasma is a common hyperpigmentation that can cause impairment of quality of life. Current melasma treatments present limitations and adjuvant treatments are of great interest.. The objective of this study was to evaluate the clinical efficacy of an oral and topical treatment based on olive extract containing hydroxytyrosol for melasma control. A pilot clinical study was conducted with 42 women with melasma, randomized m three groups of 14 participants - control, oral or topical, who received daily treatment containing hydroxytyrosol or placebo for 90 days. Melasma was evaluated once a month using the melasma area and severity index (mMASI) and the melanin and erythema index. Statistical analysis was performed using ANOVA between the groups and paired ANOVA (RM) in each group individually. The melanin index and mMASI resulted m reduced values for oral treatment, compared to the control and topical group with no significant difference (p> 0.05). However, oral treatment evaluated paired by time showed a significant reduction mn mMASI (p <0.0001) and melanin index (p = 0.0466) after 60 days. Finally, the treatments with olive extract based on hydroxytyrosol showed great potential for the control of melasma or as an adjunctive to traditional dermatological treatment.
Melasma is a common hyperpigmentation that can cause impairment of quality of life. Current melasma treatments present limitations and adjuvant treatments are of great interest.. The objective of this study was to evaluate the clinical efficacy of an oral and topical treatment based on olive extract containing hydroxytyrosol for melasma control. A pilot clinical study was conducted with 42 women with melasma, randomized m three groups of 14 participants - control, oral or topical, who received daily treatment containing hydroxytyrosol or placebo for 90 days. Melasma was evaluated once a month using the melasma area and severity index (mMASI) and the melanin and erythema index. Statistical analysis was performed using ANOVA between the groups and paired ANOVA (RM) in each group individually. The melanin index and mMASI resulted m reduced values for oral treatment, compared to the control and topical group with no significant difference (p> 0.05). However, oral treatment evaluated paired by time showed a significant reduction mn mMASI (p <0.0001) and melanin index (p = 0.0466) after 60 days. Finally, the treatments with olive extract based on hydroxytyrosol showed great potential for the control of melasma or as an adjunctive to traditional dermatological treatment.
Descrição
Biomedical and biopharmaceutical research : jornal de investigação biomédica e biofarmacêutica
Palavras-chave
MEDICINA, ESTUDOS DE CASO, COMPOSTOS FENÓLICOS, MEDICINE, CASE STUDIES, PHENOLIC COMPOUNDS, EXTRATOS VEGETAIS, VEGETAL EXTRACTS, EXTRATO DE OLIVA, OLIVE EXTRACT, MELASMA, AGENTES DESPIGMENTANTES, DEPIGMENTATION AGENTS, HIDROXITIROSOL, HYDROXYTYROSOL