Caracterização da hiperpigmentação pós inflamatória relacionada à acne por microscopia confocal de reflectância : aspectos morfológicos e estruturais
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Data
2019
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Edições Universitárias Lusófonas
Resumo
Hiperpigmentação Pós Inflamatória (HPI) é uma desordem pigmentar comum em pacientes com pele pigmentada.
Exames histológicos e clínicos são utilizados para o diagnóstico de HPI e para determinar o tratamento correto.
Entretanto, a Microscopia Confocal de Reflectância à laser (MCR) tem potencial para substituir esses métodos,
pois é uma técnica avançada de imagem, não invasiva e possui maior precisão diagnóstica do que a dermatoscopia.
O objetivo deste estudo foi caracterizar a HPI e correlacionar os principais aspectos observados por MCR às
características macroscópicas da HPI relacionada à acne. Para tal, 12 participantes de pesquisa com diagnóstico
prévio de acne e HPI foram selecionadas e avaliadas por MCR. O brilho da camada basal, a espessura da junção
dermoepidérmica (JDE) e a profundidade das papilas dérmicas foram quantificados e as características morfológicas
e estruturais da JDE foram analisadas. Os resultados mostraram aumento da pigmentação epidérmica, redução
da espessura da JDE e espessura da epiderme. Melanófagos foram observados na derme papilar, assim como
mudanças no tamanho e na forma das papilas dérmicas. Por fim, este estudo descreve as características da HPI a
fim de auxiliar os dermatologistas no diagnóstico de PIH com um método inovador que reduz o estresse associado
à biópsia histológica.
Post-Inflammatory Hyperpigmentation (PIH) is a common pigmentary disorder in patients with pigmented skin. Histological and clinical exams have been used for the diagnosis of PIH and to determine the correct treatment. However, Reflectance Confocal Microscopy (RCM) has the potential to replace these methods since it is a noninvasive advanced technique and has a higher diagnostic accuracy than dermatoscopy. The aim of this study was to characterize PIH and correlate the main aspects observed by RCM with the macroscopic characteristics of acne-related PIH. Thus, 12 subjects with previously diagnosed acne and PIH were selected for the study. PIH was evaluated by RCM. The brightness of the basal cell layer, the dermal-epidermal junction (DEJ) thickness, and the depth of dermal papillae were quantified and the morphological and structural features of the DEJ were analyzed. The results showed an increase of epidermal pigmentation, a reduction of DEJ thickness, and no change in epidermal thickness. Melanophages were observed in the papillary dermis, as well as changes in the size and shape of dermal papillae. Finally, the study describes the characteristics of PIH and can help dermatologists to diagnose PIH with an innovative method that reduces the stress associated with a histological biopsy
Post-Inflammatory Hyperpigmentation (PIH) is a common pigmentary disorder in patients with pigmented skin. Histological and clinical exams have been used for the diagnosis of PIH and to determine the correct treatment. However, Reflectance Confocal Microscopy (RCM) has the potential to replace these methods since it is a noninvasive advanced technique and has a higher diagnostic accuracy than dermatoscopy. The aim of this study was to characterize PIH and correlate the main aspects observed by RCM with the macroscopic characteristics of acne-related PIH. Thus, 12 subjects with previously diagnosed acne and PIH were selected for the study. PIH was evaluated by RCM. The brightness of the basal cell layer, the dermal-epidermal junction (DEJ) thickness, and the depth of dermal papillae were quantified and the morphological and structural features of the DEJ were analyzed. The results showed an increase of epidermal pigmentation, a reduction of DEJ thickness, and no change in epidermal thickness. Melanophages were observed in the papillary dermis, as well as changes in the size and shape of dermal papillae. Finally, the study describes the characteristics of PIH and can help dermatologists to diagnose PIH with an innovative method that reduces the stress associated with a histological biopsy
Descrição
Biomedical and biopharmaceutical research : jornal de investigação biomédica e biofarmacêutica
Palavras-chave
MEDICINA, PELE, ESTUDOS DE CASO, MEDICINE, SKIN, CASE STUDIES, HIPERPIGMENTAÇÃO, MICROSCOPIA CONFOCAL DE REFLECTÂNCIA, REFLECTANCE CONFOCAL MICROSCOPY