Topical application of a gel formulation containing Centauri honey enhances epidermal water balance in healthy skin : data from a 28-day pilot trial
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Data
2024
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Edições Universitárias Lusófonas
Resumo
O mel é um dos mais antigos produtos naturais aplicados na pele humana. No entanto, as provas científicas de alguns dos seus impactos biológicos são recentes. O nosso estudo incide sobre o impacto do mel aplicado topicamente numa pele saudável. Para o efeito, foi concebido um estudo exploratório de 28 dias que envolveu oito participantes saudáveis de ambos os sexos, selecionados de acordo com critérios previamente definidos. Este estudo duplamente cego envolveu duas formulações idênticas, sendo que apenas uma continha 5% (p/v) de um mel previamente caracterizado (mel Centauri® Turquia). As formulações foram aplicadas diariamente (0,1 ml por aplicação) durante vinte e oito dias (D0-D28) de utilização regular. A conformidade foi verificada regularmente pelos investigadores. Os resultados medidos foram a barreira "epidérmica" quantificada por evaporimetria e a hidratação epidérmica medida por técnicas electrométricas. Os resultados demonstraram que, no final do período de estudo, a formulação com mel reduziu significativamente a perda de água transepidérmica e melhorou a hidratação superficial e profunda da pele, em comparação com os respectivos controlos no D0. Resultados favoráveis semelhantes também foram obtidos com a mesma formulação após um teste de stress usando fita adesiva. Estes resultados confirmam o interesse deste ingrediente na saúde da pele, mesmo em participantes saudáveis, aspecto que deve ser mais explorado.
Honey is one of the oldest natural products applied to human skin. However, science-based evidence of some of its biological impacts are recent. Our study focuses on the impact of topically applied honey on healthy skin. To that purpose, a 28-day exploratory study was designed involving eight healthy participants of both sexes, selected following previously defined criteria. This double-blind study involved two identical formulations, where only one contained 5% (w/v) of a previously characterized honey (Centauri® honey, produced in Turkey). Formulations were applied daily (0.1 mL per application) for twenty-eight days (D0–D28) of regular use. Compliance was regularly verified by the investigators. Measured outcomes were “epidermal” barrier quantified by evaporimetry and epidermal hydration measured by electrometric techniques. Results demonstrated that at the end of the study peroid, the formulation with honey significantly reduced trans-epidermal water loss while improving both superficial and deep hydration of the skin as compared to the respective controls at D0. Similar favorable results were also obtained with the same formulation after a challenge test using tape-stripping. These results confirm the interest of this ingredient in skin health, even in healthy participants, that should be further explored.
Honey is one of the oldest natural products applied to human skin. However, science-based evidence of some of its biological impacts are recent. Our study focuses on the impact of topically applied honey on healthy skin. To that purpose, a 28-day exploratory study was designed involving eight healthy participants of both sexes, selected following previously defined criteria. This double-blind study involved two identical formulations, where only one contained 5% (w/v) of a previously characterized honey (Centauri® honey, produced in Turkey). Formulations were applied daily (0.1 mL per application) for twenty-eight days (D0–D28) of regular use. Compliance was regularly verified by the investigators. Measured outcomes were “epidermal” barrier quantified by evaporimetry and epidermal hydration measured by electrometric techniques. Results demonstrated that at the end of the study peroid, the formulation with honey significantly reduced trans-epidermal water loss while improving both superficial and deep hydration of the skin as compared to the respective controls at D0. Similar favorable results were also obtained with the same formulation after a challenge test using tape-stripping. These results confirm the interest of this ingredient in skin health, even in healthy participants, that should be further explored.
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CIÊNCIAS FARMACÊUTICAS, FISIOLOGIA HUMANA, PELE, PERDA TRANSEPIDÉRMICA DE ÁGUA, MEL, PHARMACEUTICAL SCIENCES, HUMAN PHYSIOLOGY, SKIN, TRANSEPIDERMAL WATER LOSS, HONEY
Citação
Lopes, M C, Rijo, P & Rodrigues, L M 2024, 'Topical application of a gel formulation containing Centauri honey enhances epidermal water balance in healthy skin : data from a 28-day pilot trial', Biomedical and biopharmaceutical research : jornal de investigação biomédica e biofarmacêutica, vol. 21, no. 1, pp. 43-55. https://doi.org/10.19277/bbr.21.1.346