Cymbopogon citratus (DC.) Stapf óleo essencial : desvendando potenciais benefícios na pele humana
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2022
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Edições Universitárias Lusófonas
Resumo
O óleo essencial de Cymbopogon citratus (DC.) Stapf é amplamente utilizado para a produção de fragrâncias, cosméticos e
detergentes. Entretanto, não há informações sobre os efeitos de formulações contendo óleo essencial de C. citratus (EOCC)
na pele humana. O objetivo deste estudo foi avaliar os efeitos da formulação contendo EOCC na fisiologia da pele humana.
O estudo envolveu participantes de ambos os sexos (n=12). Duas áreas (3 cm x 3 cm) foram desenhadas em ambos os
antebraços. Uma área escolhida aleatoriamente foi tratada durante 14 dias, 2 vezes/dia com gel de ácido poliacrílico contendo
5% de EOCC e a outra foi utilizada como controlo durante o mesmo período de tempo. Foram medidas perdas de água
transepidérmica (PTEA), hidratação, lípidos epidérmicos, e biomecânica (D0 e D14). Foram também obtidas imagens de
sonografia de alta resolução. Os resultados revelaram uma diminuição significativa na PTEA, um aumento significativo na
hidratação, firmeza e elasticidade, e uma diminuição nos lípidos, nas áreas tratadas com EOCC. A sonografia mostrou um
aumento da ecogenicidade da epiderme após a aplicação da formulação, indicando que o óleo essencial penetra apenas as
camadas mais superficiais da pele. Os resultados também sugerem que as formulações contendo EOCC são seguras para
aplicação tópica e podem melhorar e proteger a pele humana.
Palavras-chave: Cymbopogon citratus, óleo essencial, citral, capim-limão, erva-príncipe
The essential oil of Cymbopogon citratus (DC.) Stapf is widely used for the production of fragrances, cosmetics, and detergents. However, there is no information on the effects of formulations containing C. citratus essential oil (EOCC) on human skin. This study aimed to evaluate the effects of formulation containing EOCC on human skin physiology. The study involved participants of both sexes (n=12). Two areas (3 cm x 3 cm) were drawn on both forearms. One randomly chosen area was treated for 14 days, 2 times/day with polyacrylic acid gel containing 5% EOCC and the other was used as a control for the same time period. Transepidermal water loss (TEWL), hydration, epidermal lipids, and biomechanics were measured (D0 and D14). High resolution Sonography images were also obtained. Results revealed a significant decrease in TEWL, a significant increase in hydration, firmness and elasticity, and a decrease in lipids, in the areas treated with EOCC. Sonography showed an increase in echogenicity of the epidermis after applying the formulation indicating that the essential oil penetrates only the most superficial layers of the skin. Results also suggest that formulations containing EOCC are safe for topical application and can improve and protect human skin. Keywords: Cymbopogon citratus, essential oil, citral, lemongrass
The essential oil of Cymbopogon citratus (DC.) Stapf is widely used for the production of fragrances, cosmetics, and detergents. However, there is no information on the effects of formulations containing C. citratus essential oil (EOCC) on human skin. This study aimed to evaluate the effects of formulation containing EOCC on human skin physiology. The study involved participants of both sexes (n=12). Two areas (3 cm x 3 cm) were drawn on both forearms. One randomly chosen area was treated for 14 days, 2 times/day with polyacrylic acid gel containing 5% EOCC and the other was used as a control for the same time period. Transepidermal water loss (TEWL), hydration, epidermal lipids, and biomechanics were measured (D0 and D14). High resolution Sonography images were also obtained. Results revealed a significant decrease in TEWL, a significant increase in hydration, firmness and elasticity, and a decrease in lipids, in the areas treated with EOCC. Sonography showed an increase in echogenicity of the epidermis after applying the formulation indicating that the essential oil penetrates only the most superficial layers of the skin. Results also suggest that formulations containing EOCC are safe for topical application and can improve and protect human skin. Keywords: Cymbopogon citratus, essential oil, citral, lemongrass
Descrição
Biomedical and biopharmaceutical research : jornal de investigação biomédica e biofarmacêutica
Palavras-chave
CIÊNCIAS FARMACÊUTICAS, ÓLEOS ESSENCIAIS, PELE, PHARMACEUTICAL SCIENCES, ESSENTIAL OILS, SKIN