Improvement of patients’ antibiotic adherence : a descriptive analysis of pharmacists’ interventions
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2024
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Edições Universitárias Lusófonas
Resumo
Os farmacêuticos comunitários e hospitalares são responsáveis pela dispensa correta de antibióticos e pelo aconselhamento dos doentes. Este estudo descritivo teve como objetivo identificar as intervenções farmacêuticas potencialmente mais eficazes na melhoria da adesão dos doentes aos antibióticos baseado nos resultados de um conjunto de estudos, que foram identificados numa revisão sistemática previamente desenvolvida. Apenas ensaios controlados com avaliação do impacto das intervenções farmacêuticas na adesão dos doentes aos antibióticos i.e., grupo de intervenção vs. grupo de cuidados habituais/controlo foram convenientemente selecionados. Esses estudos foram agrupados e analisados com base na distinção entre ensaios com melhorias na adesão significativas vs. não significativas. Foram identificados 21 ensaios, mas apenas 2/3 destes ensaios apresentaram resultados estatisticamente significativos. Diversas intervenções farmacêuticas melhoraram significativamente a adesão dos doentes aos antibióticos, tais como intervenções estruturadas, a utilização de recursos visuais, aconselhamento detalhado, informações escritas, retorno de chamadas telefónicas ou a dispensa de doses personalizadas de antibióticos. É provável que uma educação farmacêutica reforçada seja especialmente relevante no caso de terapias complexas (por exemplo, tratamento de H. pylori) e/ou em doentes com baixo nível de literacia. Em conclusão, intervenções farmacêuticas estruturadas e/ou reforçadas podem melhorar significativamente a adesão dos doentes aos antibióticos em farmácias comunitárias ou hospitalares de acordo com alguns dos estudos em análise.
Community and hospital pharmacists are responsible for the correct dispensation of antibiotics and patient counselling. This descriptive study aimed to identify the potentially effective pharmacists’ interventions which improved patients’ antibiotic adherence, based on the findings of a set of studies identified in a previous developed systematic review. Only controlled trials evaluating the impact of pharmaceutical interventions on patient adherence to antibiotics, i.e., intervention group vs. usual care/control group were conveniently selected. These studies were grouped and analyzed based on the distinction between trials with significant vs. non-significant improvements on patients’adherence to antibiotics. Twenty-one trials were identified, but only 2/3 presented statistically significant results. Diverse pharmaceutical interventions significantly improved patients’ antibiotic adherence, such as structured interventions, the use of visual aids, detailed counseling, written information, call-back phone calls, or the dispensation of personalized doses of antibiotics. Reinforced pharmacist education is likely to be especially relevant in the case of complex therapies (e.g., H. pylori treatment) and/or low literacy patients. In conclusion, structured and/or reinforced pharmaceutical interventions can significantly improve patients’ antibiotic adherence in community or hospital pharmacies, according to some of the analyzed studies.
Community and hospital pharmacists are responsible for the correct dispensation of antibiotics and patient counselling. This descriptive study aimed to identify the potentially effective pharmacists’ interventions which improved patients’ antibiotic adherence, based on the findings of a set of studies identified in a previous developed systematic review. Only controlled trials evaluating the impact of pharmaceutical interventions on patient adherence to antibiotics, i.e., intervention group vs. usual care/control group were conveniently selected. These studies were grouped and analyzed based on the distinction between trials with significant vs. non-significant improvements on patients’adherence to antibiotics. Twenty-one trials were identified, but only 2/3 presented statistically significant results. Diverse pharmaceutical interventions significantly improved patients’ antibiotic adherence, such as structured interventions, the use of visual aids, detailed counseling, written information, call-back phone calls, or the dispensation of personalized doses of antibiotics. Reinforced pharmacist education is likely to be especially relevant in the case of complex therapies (e.g., H. pylori treatment) and/or low literacy patients. In conclusion, structured and/or reinforced pharmaceutical interventions can significantly improve patients’ antibiotic adherence in community or hospital pharmacies, according to some of the analyzed studies.
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Palavras-chave
PHARMACEUTICAL SCIENCES, PHARMACOLOGY, PHARMACEUTICAL CARE, PHARMACY TECHNICIANS, PHARMACIES, COMMUNITY PHARMACIES, HOSPITAL PHARMACY, ANTIBIOTICS, MEDICATION ADHERENCE, CLINICAL TRIALS, CIÊNCIAS FARMACÊUTICAS, FARMACOLOGIA, CUIDADOS FARMACÊUTICOS, TÉCNICOS DE FARMÁCIA, FARMÁCIAS, FARMÁCIAS COMUNITÁRIAS, FARMÁCIA HOSPITALAR, ANTIBIÓTICOS, ADESÃO À TERAPÊUTICA, ENSAIOS CLÍNICOS
Citação
Pires, C 2024, 'Improvement of patients’ antibiotic adherence : a descriptive analysis of pharmacists’ interventions', Biomedical and Biopharmaceutical Research, vol. 21, no. 1, pp. 109-126. https://doi.org/10.19277/bbr.21.1.337