Looking for early indicators of vascular modification in young healthy tobacco smokers
Miniatura indisponível
Data
2024
Título da revista
ISSN da revista
Título do Volume
Editora
Edições Universitárias Lusófonas
Resumo
O consumo de cigarros é um dos principais factores de risco para as doenças cardiovasculares, mas especialmente em jovens fumadores faltam indicadores precoces de dano na ausência de sinais clínicos de comprometimento. O nosso estudo identifica e compara as respostas adaptativas em jovens fumadores e em não fumadores após uma manobra de Hiperemia Reactiva (HR). O estudo observou todos os princípios da boa prática clínica, envolvendo 42 voluntários saudáveis (21 fumadores, 21 não fumadores), em tudo semelhantes, exceto no que diz respeito aos hábitos tabágicos. Os fumadores eram maioritariamente (17/21) ligeiros, de acordo com o smoking index (índice de tabagismo) calculado, tendo iniciado este consumo regular há 11,1±4,5 anos. A HR foi obtida através da aplicação de uma pressão supra-sistólica num dos braços de cada participante durante dois minutos. A perfusão foi medida no terceiro dedo do lado ipsilateral. A recuperação precoce da perfusão após a oclusão foi significativamente mais rápida nos não fumadores (***p<0,0001) em comparação com os fumadores. Estas diferenças foram atribuídas ao tabagismo, sugerindo que, mesmo na ausência de qualquer expressão clínica, as respostas adaptativas reflexas evocadas pela HR em ambos os grupos são alterados. Estes resultados justificam a realização de mais estudos para melhor compreender os impactos subclínicos precoces do tabagismo em indivíduos saudáveis.
Cigarette smoking is a main risk factor for cardiovascular disease but early indicators of damage specially in young smokers with no clinical evidence of impairment are lacking. Our study identifies adaptive responses in young smokers following a Reactive Hyperemia (RH) maneuver and compares those responses with an equivalent non-smoker group. The study respected all principles of good clinical practice, involved 42 healthy volunteers (21 smokers, 21 non-smokers), with similar anthropometric data, except for smoking habits. Smokers were mostly (17/21) mild, according with the calculated smoking index, and had followed this regular practice for 11.1±4.5 years. RH was obtained by applying a suprasystolic pressure to one of the participants' arms for two minutes. Perfusion was measured in the third finger on the ipsilateral side. Perfusion early recovery after occlusion was significantly faster in non-smokers (***p<0.0001) compared with smokers. These differences were attributed to smoking, suggesting that even in the absence of any clinical expression, the reflex adaptive responses evoked by RH in both groups are altered. These results justify further studies to better understand the early subclinical impacts of smoking on healthy individuals.
Cigarette smoking is a main risk factor for cardiovascular disease but early indicators of damage specially in young smokers with no clinical evidence of impairment are lacking. Our study identifies adaptive responses in young smokers following a Reactive Hyperemia (RH) maneuver and compares those responses with an equivalent non-smoker group. The study respected all principles of good clinical practice, involved 42 healthy volunteers (21 smokers, 21 non-smokers), with similar anthropometric data, except for smoking habits. Smokers were mostly (17/21) mild, according with the calculated smoking index, and had followed this regular practice for 11.1±4.5 years. RH was obtained by applying a suprasystolic pressure to one of the participants' arms for two minutes. Perfusion was measured in the third finger on the ipsilateral side. Perfusion early recovery after occlusion was significantly faster in non-smokers (***p<0.0001) compared with smokers. These differences were attributed to smoking, suggesting that even in the absence of any clinical expression, the reflex adaptive responses evoked by RH in both groups are altered. These results justify further studies to better understand the early subclinical impacts of smoking on healthy individuals.
Descrição
Publisher Copyright: © 2024 ALIES. All rights reserved.
Palavras-chave
MEDICINE, VASCULAR DISEASES, REACTIVE HYPEREMIA, SMOKING HABITS, YOUNG PEOPLE, MEDICINA, DOENÇAS VASCULARES, HIPEREMIA REATIVA, HÁBITOS TABÁGICOS, Biomedical and Biopharmaceutical Research Vol. 21 n.º1 (2024)
Citação
Andrade, S F & Rodrigues, L M 2024, 'Looking for early indicators of vascular modification in young healthy tobacco smokers', Biomedical and biopharmaceutical research : jornal de investigação biomédica e biofarmacêutica, vol. 21, no. 1, pp. 1-12. https://doi.org/10.19277/bbr.21.1.333