Autosomal dominant polycystic kidney disease in hemodialysis patients in southern Brazil
Miniatura indisponível
Data
10/03/2014
Título da revista
ISSN da revista
Título do Volume
Editora
Sociedade Brasileira de Nefrologia
Resumo
Introduction: Autosomal dominant polycystic
kidney disease is the most common
hereditary renal disease in humans.
Objective: To examine the prevalence,
clinical and laboratory characteristics
of patients with polycystic kidneys and
relate disease manifestations by gender.
Methods: This was an observational
and retrospective study. All the medical
records of patients with polycystic kidneys
who initiated hemodialysis between
1995 and 2012, in four centers that treat
patients of the coverage area of the 15th
regional health Paraná (Brazil), were
analyzed. Results: The study included
48 patients with polycystic kidneys, the
primary cause of stage 5 CKD. Disease
prevalence was one in 10,912 people.
The average age of dialysis initiation
was 50.7 years and the follow-up time
on dialysis until transplantation (36.5
months) was lower among men. Hypertension
was the most frequent diagnosis
in 73% of patients, predominantly in
women (51.4%). The liver cyst was the
most frequent extrarenal manifestations
in men (60.0%). The death occurred in
10.4% of patients using hemodialysis,
and 60% of men. The class of antihypertensive
drug used was that acts on
the renin-angiotensin system with higher
frequency of use among women (53.3%).
The post-dialysis urea was significantly
higher in men. Conclusion: The prevalence
of the disease is low among hemodialysis
patients in southern Brazil. The
differences observed between genders,
with the exception of the post-dialysis
urea, were not significant. The findings
are different from those reported in
North America and Europe.
Descrição
Brazilian Journal of Nephrology
Palavras-chave
DIALYSIS, EPIDEMIOLOGY, KIDNEY FAILURE, KIDNEY DISEASES, DIÁLISE, EPIDEMIOLOGIA, INSUFICIÊNCIA RENAL, DOENÇAS RENAIS
Citação
Alves Everton Fernando, Tsuneto Luiza Tamie, Pelloso Sandra Marisa, Torres Paulo Roberto Aranha, Otto Guido Luis Gomes, Silva Adaelson Alves et al . Doenca renal policistica autossomica dominante em pacientes em hemodialise no sul do Brasil. J Bras Nefrol 2014; 36(1):18-25.