Ceftriaxona: revisão clínica, consumo em Portugal e alertas de segurança
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2018
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Edições Universitárias Lusófonas
Resumo
A ceftriaxona é uma cefalosporina de 3ª geração, frequentemente prescrita devido ao amplo espectro de ação. Objetivos: (i) Elaborar uma revisão clínica da ceftriaxona. (ii) Descrever/analisar o perfil das cefalosporinas consumidas em ambulatório em Portugal por distrito em 2015. (iii) Identificar/analisar os alertas de segurança da ceftriaxona emitidos pelas agências: Nacional e Europeia do medicamento (AEM). Métodos: Foram pesquisadas diversas fontes, nomeadamente PubMed e Micromedex. Consulta do relatório do INFARMED, I.P. sobre o consumo das cefalosporinas em Portugal e dos alertas de segurança da ceftriaxona no site do INFARMED, I.P. e da AEM. Resultados: Elaboração da revisão clínica. Os distritos de Lisboa, Coimbra, Portalegre, Porto e Leiria apresentaram consumos acima da média nacional (21,25 DHD). A ceftriaxona foi a segunda cefalosporina mais consumida neste grupo. Apenas foram identificadas duas circulares informativas de segurança do INFARMED, I.P. sobre a ceftriaxona, que se basearam nas avaliações risco benefício da AEM. Conclusão: O perfil de eficácia e segurança da ceftriaxona mantem-se favorável. É possível que este antibiótico possa estar a ser prescrito fora do âmbito das suas indicações terapêuticas, tendo em conta as diferenças expressivas no seu consumo entre alguns distritos Portugueses. Assim, a vigilância do aparecimento de resistências bacterianas é fundamental.
Ceftriaxone is a 3rd generation cephalosporin, often prescribed because of its broad spectrum of action. Objectives: (i) To prepare a clinical review of ceftriaxone. (ii) To describe/analyse the profile of cephalosporins consumed in outpatient clinics by Portuguese districts in 2015. (iii) To identify/analyse the safety alerts of ceftriaxone issued by the National and European Medicines (EMA) Agencies. Methods: Diverse sources were accessed, namely PubMed and Micromedex. The report of INFARMED, I.P. on the consumption of cephalosporins in Portugal and the safety alerts of ceftriaxone on the website of INFARMED, I.P. and the EMA were consulted. Results: The clinical review was developed. The districts of Lisbon, Coimbra, Portalegre, Porto and Leiria presented consumptions above the national average (21.25 DHD). Ceftriaxone was the second most commonly used cephalosporin in this group. Only two informative circulars of INFARMED, I.P. on the safety of ceftriaxone were identified. Both circulars were based on the benefit risk assessments of EMA. Conclusion: The efficacy and safety profile of ceftriaxone remains favourable. It is possible that this antibiotic may be prescribed outside the scope of its therapeutic indications, considering the significant differences in its consumption among some Portuguese districts. Thus, monitoring for the appearance of bacterial resistance is critical.
Ceftriaxone is a 3rd generation cephalosporin, often prescribed because of its broad spectrum of action. Objectives: (i) To prepare a clinical review of ceftriaxone. (ii) To describe/analyse the profile of cephalosporins consumed in outpatient clinics by Portuguese districts in 2015. (iii) To identify/analyse the safety alerts of ceftriaxone issued by the National and European Medicines (EMA) Agencies. Methods: Diverse sources were accessed, namely PubMed and Micromedex. The report of INFARMED, I.P. on the consumption of cephalosporins in Portugal and the safety alerts of ceftriaxone on the website of INFARMED, I.P. and the EMA were consulted. Results: The clinical review was developed. The districts of Lisbon, Coimbra, Portalegre, Porto and Leiria presented consumptions above the national average (21.25 DHD). Ceftriaxone was the second most commonly used cephalosporin in this group. Only two informative circulars of INFARMED, I.P. on the safety of ceftriaxone were identified. Both circulars were based on the benefit risk assessments of EMA. Conclusion: The efficacy and safety profile of ceftriaxone remains favourable. It is possible that this antibiotic may be prescribed outside the scope of its therapeutic indications, considering the significant differences in its consumption among some Portuguese districts. Thus, monitoring for the appearance of bacterial resistance is critical.
Descrição
Biomedical and biopharmaceutical research : jornal de investigação biomédica e biofarmacêutica
Palavras-chave
MEDICINA, ANTIBIÓTICOS, FARMACOVIGILÂNCIA, CEFALOSPORINAS, MEDICINE, ANTIBIOTICS, PHARMACOVIGILANCE, CEPHALOSPORINS
Citação
Pires , C & Fernandes , A S 2018 , ' Ceftriaxona: revisão clínica, consumo em Portugal e alertas de segurança ' , Biomedical and biopharmaceutical research : jornal de investigação biomédica e biofarmacêutica . https://doi.org/10.19277/bbr.15.2.189