Síndrome metabólico
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O síndrome metabólico consiste numa associação de critérios como dislipidemia,
hipertensão, hiperglicemia, obesidade e resistência à insulina, que aumentam o risco de
doença cardiovascular.
Apesar da sua etiologia multifactorial sabe-se que existem três potenciais
categorias etiológicas: obesidade e distúrbios do tecido adiposo; resistência à insulina; e
uma multiplicidade de factores independentes. No síndrome metabólico intervêm vários
factores genéticos e ambientais tornando a sua patogénese bastante complexa e não
inteiramente conhecida, porém sabe-se que a combinação de excessos alimentares,
inatividade, factores genéticos entre outros interagem para produzir um estado de
desregulação metabólica.
No tratamento deste síndrome é essencial a modificação do estilo de vida, com
uma dieta equilibrada e prática de exercício físico. A terapêutica não farmacológica é a
primeira escolha para uma intervenção inicial. O tratamento farmacológico só deve ser
aplicado quando as medidas não farmacológicas são ineficazes para a redução dos factores
de risco.
Em suma, a prevenção do síndrome metabólico é fundamental, dado que este
constitui um importante problema de saúde pública. A prevalência do síndrome pode, por
isso, ser reduzida com recurso a importantes medidas de saúde pública com impacto sobre
a população.
The metabolic syndrome is a combination of criteria such as dyslipidemia, hypertension, hyperglycemia, obesity and insulin resistance, that increases the risk of cardiovascular disease. Despite its multifactorial etiology it is known that there are three potential etiologic categories: obesity and adipose tissue disorders; insulin resistance; and a plurality of independent factors. Metabolic syndrome involves several genetic and environmental factors, making its pathogenesis highly complex and not entirely known. Still, it is known that the combination of overfeeding, inactivity, genetic factors and other factors result in a metabolic deregulation state. In order to treat this syndrome, it is essential a lifestyle change with specific focus on diet and exercise. The first choice for an early intervention should be a nonpharmacological treatment. Pharmacological treatment should only be applied when nonpharmacological measures weren’t effective in the reduction of risk factors. In conclusion, the metabolic syndrome prevention is critical, since this represents a major public health problem. The syndrome prevalence can therefore, be reduced with the use of important public health measures. affecting the population.
The metabolic syndrome is a combination of criteria such as dyslipidemia, hypertension, hyperglycemia, obesity and insulin resistance, that increases the risk of cardiovascular disease. Despite its multifactorial etiology it is known that there are three potential etiologic categories: obesity and adipose tissue disorders; insulin resistance; and a plurality of independent factors. Metabolic syndrome involves several genetic and environmental factors, making its pathogenesis highly complex and not entirely known. Still, it is known that the combination of overfeeding, inactivity, genetic factors and other factors result in a metabolic deregulation state. In order to treat this syndrome, it is essential a lifestyle change with specific focus on diet and exercise. The first choice for an early intervention should be a nonpharmacological treatment. Pharmacological treatment should only be applied when nonpharmacological measures weren’t effective in the reduction of risk factors. In conclusion, the metabolic syndrome prevention is critical, since this represents a major public health problem. The syndrome prevalence can therefore, be reduced with the use of important public health measures. affecting the population.
Descrição
Orientação : Liliana Tavares Marques
Palavras-chave
MESTRADO INTEGRADO EM CIÊNCIAS FARMACÊUTICAS, CIÊNCIAS FARMACÊUTICAS, HIPERTENSÃO, OBESIDADE, DOENÇAS CARDIOVASCULARES, INSULINA, COLESTEROL, HIPERGLICEMIA, PHARMACEUTICAL SCIENCES, HYPERTENSION, OBESITY, CARDIOVASCULAR DISEASES, INSULIN, CHOLESTEROL, HYPERGLYCEMIA, TERAPÊUTICAS, THERAPEUTICS, DISLIPIDEMIAS, DYSLIPIDEMIAS