Avaliação dos recetores de estrogénio e de progesterona em lesões benignas mamárias de gatas e a sua correlação com parâmetros clinicopatológicos
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2021
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A influência das hormonas nas neoplasias mamárias justificou a avaliação da expressão dos recetores hormonais através da caracterização da expressão genética, bem como da imunohistoquímica. O presente estudo teve como objetivo, tanto a caracterização de uma população felina em relação às lesões benignas neoplásicas e não neoplásicas, como realizar a correlação entre a presença de recetores de estrogénio (RE) e recetores de progesterona (RP) com diferentes parâmetros clínicos e histopatológicos, e comparar os resultados obtidos com a literatura existente. Incluíram-se 28 fêmeas no estudo, foram avaliadas e registadas 8 características clinicopatológicas e 4 características histopatológicas. Concluiu-se que, animais mais jovens, têm tendência para apresentar maior expressão dos RE e RP nos seus tumores e que, tumores de maiores dimensões, estão associados a animais com diminuição da expressão de RP. Foi possível concluir ainda que o animal estar esterilizado e ter lesão displásica, tem uma grande influência positiva na sobre expressão de recetores de progesterona, e que, a existência de tumores malignos associados está mais correlacionada com a inexistência de sobre expressão de recetores de progesterona.
The influence of hormones on mammary neoplasms justified the evaluation of the expression of hormone receptors through the characterization of gene expression as well as immunohistochemistry. The present study aimed both to characterize a feline population in relation to neoplastic and non-neoplastic benign lesions, and to perform the correlation between the presence of estrogen receptors (RE) and progesterone receptors (RP) with different clinical and histopathological parameters, and to compare the results obtained with the existing literature. 28 females were included in the study, 8 clinicopathological and 4 histopathological features were evaluated and recorded. It was concluded that younger animals have a tendency to present an higher expression of RE and RP in their tumors and that larger tumors are associated to animals with a decreased expression of RP. It was also possible to conclude that being sterilized and having a dysplastic lesion have a great positive influence on the over expression of progesterone receptors, and that the existence of associated malignant tumors is more correlated with the absence of over expression of progesterone receptors.
The influence of hormones on mammary neoplasms justified the evaluation of the expression of hormone receptors through the characterization of gene expression as well as immunohistochemistry. The present study aimed both to characterize a feline population in relation to neoplastic and non-neoplastic benign lesions, and to perform the correlation between the presence of estrogen receptors (RE) and progesterone receptors (RP) with different clinical and histopathological parameters, and to compare the results obtained with the existing literature. 28 females were included in the study, 8 clinicopathological and 4 histopathological features were evaluated and recorded. It was concluded that younger animals have a tendency to present an higher expression of RE and RP in their tumors and that larger tumors are associated to animals with a decreased expression of RP. It was also possible to conclude that being sterilized and having a dysplastic lesion have a great positive influence on the over expression of progesterone receptors, and that the existence of associated malignant tumors is more correlated with the absence of over expression of progesterone receptors.
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Orientação: Maria João Soares
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MESTRADO INTEGRADO EM MEDICINA VETERINÁRIA, MEDICINA VETERINÁRIA, VETERINÁRIA, FELÍDEOS, GATOS, IMUNOHISTOQUÍMICA, VETERINARY MEDICINE, FELIDS, CATS, IMMUNOHISTOCHEMISTRY, LESÕES MAMÁRIAS, MAMMARY LESIONS, RECETORES DE ESTROGÉNIO, ESTROGEN RECEPTORS, RECEPTORES DE PROGESTERONA, PROGESTERONE RECEPTORS