Avaliação da utilidade da imunohistoquímica para deteção de micrometástases ocultas em carcinomas mamários em gatos
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2022
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Os tumores mamários em gatos são a terceira neoplasia mais comum nesta espécie, sendo a maioria carcinomas mamários do tipo simples. A taxa de malignidade dos tumores mamários é de 85% sendo frequente a metastatização em linfonodos, pulmões, e menos frequentemente, fígado e pleura. Os linfonodos regionais apresentam um papel fundamental para o prognóstico do animal. Devido à elevada densidade celular dos linfonodos, por vezes, as micrometástases não são detetadas pelo método convencional de diagnóstico. A técnica de imunohistoquímica é muito utilizada em Medicina Humana e é, cada vez mais, utilizada como uma técnica de diagnóstico auxiliar em Medicina Veterinária
Breast tumors in cats are the third most common neoplasm in this species, most being simple type mammary carcinomas. The malignancy rate of mammary tumors is 85%, and metastasization to lymph nodes, lungs, and less frequently, liver and pleura is frequent. Regional lymph nodes play a key role in the animal's prognosis. Due to the high cell density of the lymph nodes, sometimes micrometastases are not detected by the conventional diagnostic method. The immunohistochemistry technique is widely used in human medicine and is increasingly used as an auxiliary diagnostic technique in veterinary medicine. This study aimed to evaluate the immunohistochemistry technique with the antibodies AE1/AE3 in the detection of occult micrometastases in regional lymph nodes of mammary chains previously diagnosed as negative by the conventional method of diagnosis, in cats with mammary carcinomas. This consisted of 100 cases of mammary carcinomas in cats and 125 regional lymph nodes. Using the immunohistochemistry technique, 11% of the cases were found to have metastases, of which 5% were occult micrometastases. This study showed the contribution of immunohistochemistry in the detection of occult micrometastases in regional lymph nodes of cats.
Breast tumors in cats are the third most common neoplasm in this species, most being simple type mammary carcinomas. The malignancy rate of mammary tumors is 85%, and metastasization to lymph nodes, lungs, and less frequently, liver and pleura is frequent. Regional lymph nodes play a key role in the animal's prognosis. Due to the high cell density of the lymph nodes, sometimes micrometastases are not detected by the conventional diagnostic method. The immunohistochemistry technique is widely used in human medicine and is increasingly used as an auxiliary diagnostic technique in veterinary medicine. This study aimed to evaluate the immunohistochemistry technique with the antibodies AE1/AE3 in the detection of occult micrometastases in regional lymph nodes of mammary chains previously diagnosed as negative by the conventional method of diagnosis, in cats with mammary carcinomas. This consisted of 100 cases of mammary carcinomas in cats and 125 regional lymph nodes. Using the immunohistochemistry technique, 11% of the cases were found to have metastases, of which 5% were occult micrometastases. This study showed the contribution of immunohistochemistry in the detection of occult micrometastases in regional lymph nodes of cats.
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Orientação: Pedro Faísca
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MESTRADO INTEGRADO EM MEDICINA VETERINÁRIA, MEDICINA VETERINÁRIA, VETERINÁRIA, FELÍDEOS, GATOS, IMUNOHISTOQUÍMICA, VETERINARY MEDICINE, FELIDS, CATS, IMMUNOHISTOCHEMISTRY, LINFONODOS, LYMPH NODES, MICROMETÁSTESES