Mastocitoma cutâneo canino e inflamação cutânea crónica
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2019
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Os mastocitomas cutâneos representam a neoplasia cutânea maligna mais comum na
população canina, constituindo cerca de 16 a 21% das neoplasias cutâneas. Tratam-se de
neoplasias algo heterogéneas, de prognóstico bastante variável.
Alguns estudos parecem revelar uma etilogia multifactorial para o mastocitoma, mas
existe pouca evidência. Várias linhas de pensamento sugerem o desenvolvimento de neoplasias
em locais de inflamação crónica, tanto em medicina humana como em medicina veterinária.
Neste trabalho colocou-se a hipótese de uma possível associação entre a inflamação cutânea
crónica e o desenvolvimento desta neoplasia.
Através da análise retrospectiva, pretendeu-se estudar a possível correlação entre
mastocitomas cutâneos caninos e a história pregressa de inflamação cutânea crónica,
nomeadamente a presença de patologias cutâneas sem diagnóstico definitivo (PCSDD), atopia,
otites crónicas e reacção adversa ao alimento.
Deste modo, foram selecionados 79 casos de cães diagnosticados com mastocitoma
cutâneo entre Janeiro de 2015 e Junho de 2019, do Rosemary Lodge Veterinary Hospital, em
Bath, Inglaterra, perfazendo um total de 107 massas cutâneas.
Conclui-se que a grande maioria dos animais do estudo apresentava história pregressa
de inflamação cutânea crónica e que as formas mais comuns de manifestação de inflamação
foram as patologias cutâneas sem diagnóstico definitivo e as otites crónicas.
Foi também possível verificar a concordância com a bibliografia em algumas das
variáveis do estudo nomeadamente, as raças com maior predisposição para o desenvolvimento
de mastocitoma, a idade dos animais afectados pela doença, distribuição de grau histológico e
uma maior sobrevida para animais com mastocitomas completamente removidos.
Mast cell tumors represent the most common cutaneous malignant mass in dogs resulting in 16% and 21% of all cutaneous tumors. This tumor is somewhat heterogeneous and its prognosis is known for being very variable. Some studies suggest a multifactorial etiology for this tumor although there is not much evidence. Some lines of inquiry suggest the development of neoplasms at sites of chronic inflammation in both human and veterinary medicine. In this dissertation a relation was hypothesized between chronic skin inflammation and the development of this neoplasm. The primary goal of this retrospective statistic analysis was to study a potential correlation between chronic skin inflammation and mast cell tumor development in dogs. The presence of atopy, chronic otitis, food allergy reaction as well as skin pathologies with no final diagnosis were considered. Approximately 79 cases of dogs previously diagnosed with mast cell tumors were selected, between January 2015 and June 2019, from the Rosemary Lodge Veterinary Hospital, in Bath, UK, soming up a total of 107 mast cell tumors. This study concluded that a large majority of the animals had a past history of chronic skin inflammation and that the most commom forms of inflammation were skin pathologies without a definitive diagnosis and chronic otitis. It was also possible to find, according to the literature, the breeds with greater predisposition for development of the disease, age of the animals affect by this neoplasm, histological grade distribution and longer survival time for the animals with completely removed mast cell tumors.
Mast cell tumors represent the most common cutaneous malignant mass in dogs resulting in 16% and 21% of all cutaneous tumors. This tumor is somewhat heterogeneous and its prognosis is known for being very variable. Some studies suggest a multifactorial etiology for this tumor although there is not much evidence. Some lines of inquiry suggest the development of neoplasms at sites of chronic inflammation in both human and veterinary medicine. In this dissertation a relation was hypothesized between chronic skin inflammation and the development of this neoplasm. The primary goal of this retrospective statistic analysis was to study a potential correlation between chronic skin inflammation and mast cell tumor development in dogs. The presence of atopy, chronic otitis, food allergy reaction as well as skin pathologies with no final diagnosis were considered. Approximately 79 cases of dogs previously diagnosed with mast cell tumors were selected, between January 2015 and June 2019, from the Rosemary Lodge Veterinary Hospital, in Bath, UK, soming up a total of 107 mast cell tumors. This study concluded that a large majority of the animals had a past history of chronic skin inflammation and that the most commom forms of inflammation were skin pathologies without a definitive diagnosis and chronic otitis. It was also possible to find, according to the literature, the breeds with greater predisposition for development of the disease, age of the animals affect by this neoplasm, histological grade distribution and longer survival time for the animals with completely removed mast cell tumors.
Descrição
Orientação: Joana Oliveira ; co-orientação: Ana Rita Serras
Palavras-chave
MESTRADO INTEGRADO EM MEDICINA VETERINÁRIA, VETERINÁRIA, MEDICINA VETERINÁRIA, CANÍDEOS, CÃES, MASTOCITOMAS, INFLAMAÇÕES, ANÁLISE DE SOBREVIVÊNCIA, VETERINARY MEDICINE, DOGS, CANIDS, MAST CELL TUMOR, INFLAMMATION, SURVIVAL ANALYSIS