Relationship between blood biomarkers, physical fitness, quality of life and cognitive function in older adults with Alzheimer disease
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2021
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Introdução: A doença de Alzheimer (DA) é a doença neurodegenerativa mais comum,
afetando milhões de pessoas. Esta doença progressiva afeta a capacidade cognitiva e
funcional, levando à deterioração da qualidade de vida (QdV) do paciente e do cuidador em
todos os estados da doença. No entanto, a literatura carece de informações acerca da
interação e do papel de biomarcadores sanguíneos específicos assim como da saúde física e
mental na QdV em indivíduos com distúrbios neurocognitivos, incluindo DA. Objetivos:
Este estudo visa caracterizar a composição corporal, aptidão física e biomarcadores
sanguíneos (perfis metabólicos, inflamatórios, neurotróficos e antioxidantes totais) de
acordo com a QdV, assim como determinar a correlação entre os componentes da aptidão
física e a função cognitiva em indivíduos com distúrbios neurocognitivos,. Métodos: Os
participantes deste estudo transversal foram 34 idosos [71,4% mulheres; 74,06 ± 6,03 anos,
com diagnóstico médico de distúrbio neurocognitivo (doença de Alzheimer, demência
vascular ou demência a mista)] categorizados de acordo com o percentil 50 [Baixa QdV
(≤30,17) ou Alta QdV (>30,17)] avaliado através do questionário QoL-AD. Foram
recolhidos dados sociodemográficos, clínicos, composição corporal, antropométrica,
avaliação cognitiva (Mini Exame do Estado Mental), aptidão física (Senior Fitness Test) e
amostras de sangue para análise de biomarcadores. Resultados: Os grupos de QdV não
apresentaram diferenças para idade, sexo, escolaridade, duração do diagnóstico de transtorno
neurocognitivo principal e função cognitiva. O grupo com QdV alta comparado ao grupo
QdV baixa apresentou melhores níveis de força na parte inferior do corpo (12,47 ± 2,81 vs.
9,59 ± 4,03 respetivamente; p = 0,021). Não foram encontradas diferenças significativas nas
variáveis de composição corporal, aptidão aeróbia, agilidade ou força de membros
superiores de acordo com os níveis de QdV (p> 0,05). O grupo com Alta QdV em
comparação com o grupo de Baixa QdV, apresentou níveis mais elevados de IGF-1 (161,00
± 37,82 Vs. 126,13 ± 32,42, respetivamente; p = 0,046) BDNF (31285,00 ± 4798,55
Vs,2577,00 ± 4873,46, respetivamente; p = 0,022) e z-score neurotrófico (composto de IGF-
1, VEGF-1 e BDNF, 0,26 ± 0,48 Vs. -0,40 ± 0,31, respetivamente; p = 0,025). Todos os
componentes da aptidão física avaliados foram significativamente correlacionados com a função cognitiva (p <0,05). Conclusão: A QdV parece estar relacionada com maior aptidão
física e desfechos neurotróficos. Estratégias para melhorar a QdV podem sustentar a saúde
física e mental em indivíduos com distúrbios neurocognitivos. Os componentes da aptidão
física parecem ser importantes para a função cognitiva e, portanto, a atividade física deve
ser aconselhada para indivíduos idosos com DA.
Background: Alzheimer disease (AD) is the most common neurodegenerative disorder, affecting millions of people. This progressive disease affects cognitive and functional capacity, leading to the deterioration of both patient and caregiver quality of life (QoL) across disease states. However, there is a lack of information about disease biomarkers and physical and mental health according to QoL in individuals with major neurocognitive disorders, including AD. Aims: The study aims to characterize body composition, physical fitness and blood biomarkers (metabolic, inflammatory, neurotrophic profiles, and total antioxidant), according to QoL and to characterize the correlation between physical fitness and cognitive function in older people with neurocognitive disorders, particularly with AD. Methods: The participants of this cross-sectional study comprised 34 older adults [71.4% women; 74.06 ± 6.03 yrs, with a medical diagnosis of major neurocognitive disorder (Alzheimer disease, Vascular dementia or Mixed dementia)] were categorized according to 50th percentile [Low (≤30.17) or High (>30.17)] for quality of life (QoL) assessed using the QoL-AD scale – Questionnaire. Sociodemographic, clinical data, body composition, anthropometric, cognitive assessment (Mini Mental State Examination, MMSE), physical fitness (Senior Fitness Test) and blood samples were collected for biomarkers analysis. Results: QoL groups were not different for age, sex, education, duration of major neurocognitive disorder diagnose and cognitive function. High QoL group compared to low QoL have better levels of lower body strength (12.47 ± 2.81 Vs. 9.59 ± 4.03 respectively; p = 0.021). No significant differences were found in body composition, aerobic fitness, agility or upper body strength variable's according to QoL levels (p>0.05). High compared to low QoL group, showed higher levels of IGF-1 (161.00 ± 37.82 Vs. 126.13 ± 32.42, respectively p = 0.046) BDNF (31285.00 ± 4798.55 Vs.2577.00 ± 4873.46, respectively p = 0.022) and neurotrophic z-score (composite of IGF-1, VEGF-1 and BDNF, 0.26 ± 0.48 Vs. -0.40 ± 0.31, respectively; p = 0.025). Additionally, all of physical fitness components evaluated were significantly correlated with cognitive function (p<0.05). Conclusion: QoL seem to be related to higher physical fitness and neurotrophic outcomes. Strategies to improve QoL might sustain physical and mental health in individuals with neurocognitive disorders. Physical fitness components seem to be important for cognitive function and therefore physical activity should be advised for older adults with AD..
Background: Alzheimer disease (AD) is the most common neurodegenerative disorder, affecting millions of people. This progressive disease affects cognitive and functional capacity, leading to the deterioration of both patient and caregiver quality of life (QoL) across disease states. However, there is a lack of information about disease biomarkers and physical and mental health according to QoL in individuals with major neurocognitive disorders, including AD. Aims: The study aims to characterize body composition, physical fitness and blood biomarkers (metabolic, inflammatory, neurotrophic profiles, and total antioxidant), according to QoL and to characterize the correlation between physical fitness and cognitive function in older people with neurocognitive disorders, particularly with AD. Methods: The participants of this cross-sectional study comprised 34 older adults [71.4% women; 74.06 ± 6.03 yrs, with a medical diagnosis of major neurocognitive disorder (Alzheimer disease, Vascular dementia or Mixed dementia)] were categorized according to 50th percentile [Low (≤30.17) or High (>30.17)] for quality of life (QoL) assessed using the QoL-AD scale – Questionnaire. Sociodemographic, clinical data, body composition, anthropometric, cognitive assessment (Mini Mental State Examination, MMSE), physical fitness (Senior Fitness Test) and blood samples were collected for biomarkers analysis. Results: QoL groups were not different for age, sex, education, duration of major neurocognitive disorder diagnose and cognitive function. High QoL group compared to low QoL have better levels of lower body strength (12.47 ± 2.81 Vs. 9.59 ± 4.03 respectively; p = 0.021). No significant differences were found in body composition, aerobic fitness, agility or upper body strength variable's according to QoL levels (p>0.05). High compared to low QoL group, showed higher levels of IGF-1 (161.00 ± 37.82 Vs. 126.13 ± 32.42, respectively p = 0.046) BDNF (31285.00 ± 4798.55 Vs.2577.00 ± 4873.46, respectively p = 0.022) and neurotrophic z-score (composite of IGF-1, VEGF-1 and BDNF, 0.26 ± 0.48 Vs. -0.40 ± 0.31, respectively; p = 0.025). Additionally, all of physical fitness components evaluated were significantly correlated with cognitive function (p<0.05). Conclusion: QoL seem to be related to higher physical fitness and neurotrophic outcomes. Strategies to improve QoL might sustain physical and mental health in individuals with neurocognitive disorders. Physical fitness components seem to be important for cognitive function and therefore physical activity should be advised for older adults with AD..
Descrição
Orientação: Inês Marques Aleixo ; coorientação: Lucimére Bohn
Palavras-chave
MESTRADO EM EXERCÍCIO E BEM-ESTAR, DESPORTO, EDUCAÇÃO FÍSICA, DOENÇA DE ALZHEIMER, EXERCÍCIO FÍSICO, FITNESS, BIOMARCADORES, SANGUE, QUALIDADE DE VIDA, SPORT, PHYSICAL EDUCATION, ALZHEIMER'S DISEASE, PHYSICAL EXERCISE, BIOMARKERS, BLOOD, QUALITY OF LIFE