Emulsões O/A contendo rutina: impacto dos líquidos iónicos na sua estabilidade
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Data
2022
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O desenvolvimento de sistemas de veiculação de fármacos tópicos tem despertado um interesse crescente. No entanto, algumas limitações podem surgir durante o desenvolvimento destes, como a baixa solubilidade de certos ativos, a dificuldade de incorporação desses mesmos ativos nos sistemas de veiculação e até mesmo a desafios na estabilidade desses sistemas. Os Líquidos Iónicos (LI) têm várias propriedades que podem ser benéficas para este desafio, pois podem aumentar a solubilidade e facilitar a incorporação de compostos pouco solúveis em diferentes tipos de formulações, e também está descrito que podem aumentar a estabilidade de formulações.
A rutina é um composto fenólico com propriedades interessantes do ponto de vista farmacológico, porém a sua baixa solubilidade limita a sua aplicabilidade.
No âmbito deste estudo, foi avaliado a incorporação de rutina em emulsões óleo em água (O/A), tanto na presença como na ausência de rutina e/ou de LI e foi avaliado qual o impacto destes sais na estabilidade das emulsões preparadas na presença de diferentes quantidades de emulsificante.
Após a execução de estudos de solubilidade, onde ficou comprovado que os dois LI estudados permitem um aumento de solubilidade da rutina em água, foram preparadas formulações O/A, na ausência e presença de rutina e/ou dos LI estudados e foram executados estudos de estabilidade das formulações. Os resultados obtidos possibilitaram concluir que a presença dos LI permitiu uma maior facilidade na formulação e uma maior estabilidade das formulações desenvolvidas permitindo utilizar menores quantidades do emulsificante Crodafos® CES.
Palavras-chave: Rutina, Líquidos Iónicos, Solubilidade, Emulsões Óleo/Água, Estabilidade, Armazenamento.
The development of drug delivery systems has attracted growing interest. However, some limitations may arise during their development, such as the low solubility of some compounds, difficulty in incorporating them in the delivery systems and even challenges in the stability of the systems. Ionic Liquids (IL) have several properties that can be beneficial for this challenge, as they can increase solubility and facilitate the incorporation of poorly soluble compounds in different types of formulations, and it has also been described that they can increase the stability of formulations. Rutin is a phenolic compound with interesting properties from a pharmacological point of view, however its low solubility limits its applicability. Within the scope of this study, the incorporation of rutin in oil in water (O/W) emulsions in the presence and absence of rutin and/or IL was evaluated and the impact of these salts on the stability of the developed formulations in the presence of different amounts of emulsifier was evaluated. Initially, solubility studies were carried out, where it was proven that the two IL allow an increase in the solubility of rutin in water. Then O/W formulations were developed, in the absence and presence of rutin and / or the studied IL and stability studies of the formulations were carried out. The results obtained allowed to conclude that the presence of IL allowed a greater ease in the formulation and a superior stability of the formulations developed allowing the use of smaller amounts of the emulsifier Crodafos® CES. Keywords: Rutin, Ionic liquids, Solubility, Oil-in-water emulsions, Stability, Shelf-life.
The development of drug delivery systems has attracted growing interest. However, some limitations may arise during their development, such as the low solubility of some compounds, difficulty in incorporating them in the delivery systems and even challenges in the stability of the systems. Ionic Liquids (IL) have several properties that can be beneficial for this challenge, as they can increase solubility and facilitate the incorporation of poorly soluble compounds in different types of formulations, and it has also been described that they can increase the stability of formulations. Rutin is a phenolic compound with interesting properties from a pharmacological point of view, however its low solubility limits its applicability. Within the scope of this study, the incorporation of rutin in oil in water (O/W) emulsions in the presence and absence of rutin and/or IL was evaluated and the impact of these salts on the stability of the developed formulations in the presence of different amounts of emulsifier was evaluated. Initially, solubility studies were carried out, where it was proven that the two IL allow an increase in the solubility of rutin in water. Then O/W formulations were developed, in the absence and presence of rutin and / or the studied IL and stability studies of the formulations were carried out. The results obtained allowed to conclude that the presence of IL allowed a greater ease in the formulation and a superior stability of the formulations developed allowing the use of smaller amounts of the emulsifier Crodafos® CES. Keywords: Rutin, Ionic liquids, Solubility, Oil-in-water emulsions, Stability, Shelf-life.
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Orientação: Tânia Santos de Almeida
Palavras-chave
MESTRADO INTEGRADO EM CIÊNCIAS FARMACÊUTICAS, CIÊNCIAS FARMACÊUTICAS, LÍQUIDOS IÓNICOS, SOLUBILIDADE, ESTABILIDADE DE MEDICAMENTOS, PHARMACEUTICAL SCIENCES, IONIC LIQUIDS, SOLUBILITY, DRUG STABILITY, RUTINA, RUTIN, EMULSÕES ÓLEO/ÁGUA, OIL-IN-WATER EMULSIONS