Synthesis of bioactive royleanone derivatives from Plectranthus spp.

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dc.contributor.advisorRijo, Patrícia, orient.
dc.contributor.authorPereira, Ana Raquel Bento
dc.date.accessioned2022-01-28T16:06:22Z
dc.date.available2022-01-28T16:06:22Z
dc.date.embargo20/05/2024
dc.date.issued2020
dc.descriptionOrientação: Patricia Rijopt
dc.description.abstractCancer is one of the most common causes of death worldwide. The growing incidence of cancer and the development of multidrug resistance has driven the search for novel and more effective drugs. Plants have been used for their medicinal properties since ancient times. In developing countries, herbal preparations are still a major way of disease prevention and treatment considering their availability and cost in comparison to medicines. Abietane diterpenoids mainly royleanones are bioactive compounds frequently found in the Plectranthus genus (Lamiaceae family). P. madagascariensis (Pers.) Benth essential oil is rich in 6-7-dehydroxyroyleanone (DHR), a cytotoxic royleanone. DHR molecule possesses hydroxyl groups suitable for derivatization, which have drawn attention to the possibility of exploring its reactivity to improve its cytotoxic potential. In this work, several hemi-synthetic reactions were performed, resourcing to reactions of carbamoylation and esterification. These reaction products were fully structurally characterized mainly by spectroscopic methods and afforded three unstable carbamoylation derivatives and three stable ester derivatives with overall good yields (86-95%). The three stable derivatives were also submitted to biological studies to access their antimicrobial activity,general toxicity, and cytotoxicity. The biological activity of all diterpenoids found in the literature was compared to understand which chemical features are important to identify and design hit molecules.pt
dc.formatapplication/pdf
dc.identifier.tid202787630pt
dc.identifier.urihttp://hdl.handle.net/10437/12576
dc.language.isoengpt
dc.rightsembargoedAccess
dc.subjectMESTRADO INTEGRADO EM CIÊNCIAS FARMACÊUTICASpt
dc.subjectCIÊNCIAS FARMACÊUTICASpt
dc.subjectCANCROpt
dc.subjectPLANTAS MEDICINAISpt
dc.subjectPHARMACEUTICAL SCIENCESen
dc.subjectCANCERen
dc.subjectMEDICINAL PLANTSen
dc.titleSynthesis of bioactive royleanone derivatives from Plectranthus spp.pt
dc.typemasterThesispt

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Mestrado Integrado em Ciências Farmacêuticas
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