Incorporação de gelucire e de um líquido iónico em implantes lipídicos
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Data
2019
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A emergência de novos fármacos com problemas no âmbito da veiculação, bem como a necessidade de melhoria das características das moléculas já existentes no mercado, tornou imprescindível a busca por novas tecnologias de administração de fármacos, para alcançar o efeito terapêutico desejado.
Os sistemas de libertação controlada, nomeadamente os implantes lipídicos, podem servir como uma via alternativa que permite superar muitos destes obstáculos inerentes a fármacos cujas características os impedem de ser administrados nas concentrações e taxas necessárias.
O uso de implantes lipídicos pode assim aumentar a eficácia do tratamento farmacológico através da redução da dose e do número de administrações, reduzindo possíveis efeitos secundários, aumentando a qualidade de vida e a compliance dos doentes, sendo fundamental perceber a influência da sua composição no processo de libertação. As manipulações do tipo de constituintes presentes nestes implantes podem conduzir a uma maior eficiência deste tipo de sistemas.
Os líquidos iónicos (LI), são reconhecidos pelas suas inúmeras propriedades valiosas, como permitirem aumentar a solubilidade e até a permeação de muitos fármacos. As suas propriedades como promotores da solubilidade podem trazer uma mais valia, enquanto componentes dos sistemas de veiculação.
Assim, neste trabalho, pretendeu-se produzir implantes lipídicos contendo Dynasan, Dynasan/Gelucire e Dynasan/Gelucire/LI e avaliar o efeito dessas variações de composição na uniformidade dos implantes produzidos bem como no doseamento, e libertação da cafeína, usado como fármaco modelo. Os resultados obtidos permitiram concluir que os diferentes excipientes usados não comprometeram a qualidade dos implantes produzidos e que o LI aumenta o perfil de libertação do fármaco estudado.
The emergence of new pharmaceutical molecules with complications in terms of delivery, as well as the need of improvement of the molecules that are already on the market, made the search of new technologies for drug administracion crucial, to achieve a proper pharmaceutical effect. Systems of controlled drug release, in particular, lipidic implants, may serve as an alternative that can overcome many of these obstacles, inherent to drugs whose characteristics are a deterrent to the appropriate administracion profiles and rates. The use of lipidic implants can improve the efficacy of the pharmacological treatment trough the reduction of dosage and the number of administracions, reducing possible side effects, enhancing the quality of life and patient compliance, being fundamental to understand the influence of their composition in the delivery process. The manipulation of the type of the constituents present in these implants can allow for increased efficiency on this type of systems. Ionic liquids (IL) are recognized for their multiple valuable proprieties, such as the solubility and permeability enhancement of many drugs. Thus, their proprieties as solubility promoters can be an asset, as components of delivery systems. In this work, it was intended to produce lipidic implants containing Dynasan, Dynasan/Gelucire and Dynasan/Gelucire/IL and to evaluate how these differences in composition impact the content uniformity of the implants produced, as well as on the caffeine release and content, which was used as the model drug. The results allowed to reach the conclusion that the different excipients used did not compromise the quality of the implants produced and that the IL enhances the profile release of the studied drug.
The emergence of new pharmaceutical molecules with complications in terms of delivery, as well as the need of improvement of the molecules that are already on the market, made the search of new technologies for drug administracion crucial, to achieve a proper pharmaceutical effect. Systems of controlled drug release, in particular, lipidic implants, may serve as an alternative that can overcome many of these obstacles, inherent to drugs whose characteristics are a deterrent to the appropriate administracion profiles and rates. The use of lipidic implants can improve the efficacy of the pharmacological treatment trough the reduction of dosage and the number of administracions, reducing possible side effects, enhancing the quality of life and patient compliance, being fundamental to understand the influence of their composition in the delivery process. The manipulation of the type of the constituents present in these implants can allow for increased efficiency on this type of systems. Ionic liquids (IL) are recognized for their multiple valuable proprieties, such as the solubility and permeability enhancement of many drugs. Thus, their proprieties as solubility promoters can be an asset, as components of delivery systems. In this work, it was intended to produce lipidic implants containing Dynasan, Dynasan/Gelucire and Dynasan/Gelucire/IL and to evaluate how these differences in composition impact the content uniformity of the implants produced, as well as on the caffeine release and content, which was used as the model drug. The results allowed to reach the conclusion that the different excipients used did not compromise the quality of the implants produced and that the IL enhances the profile release of the studied drug.
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Orientação: Tânia Santos de Almeida
Palavras-chave
CIÊNCIAS FARMACÊUTICAS, FARMACOLOGIA, SISTEMAS DE LIBERTAÇÃO DE MEDICAMENTOS, LÍQUIDOS IÓNICOS, PHARMACEUTICAL SCIENCES, PHARMACOLOGY, DRUG DELIVERY SYSTEMS, IONIC LIQUIDS, MESTRADO INTEGRADO EM CIÊNCIAS FARMACÊUTICAS, IMPLANTES LIPÍDICOS, LIPIDIC IMPLANTS