Efeitos adversos associados à eletroquimioterapia em gatos com carcinoma das células escamosas: estudo retrospetivo
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Data
2019
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Resumo
O carcinoma das células escamosas (CCE) é uma neoplasia maligna, com origem no epitélio
escamoso, que representa cerca de 10% a 15% das neoplasias cutâneas e cerca de 60 a 70%
das neoplasias orais em gatos. A eletroquimioterapia (EQT) é uma modalidade terapêutica
direcionada a neoplasias cutâneas e subcutâneas, que tem vindo a ganhar popularidade, tanto
em Medicina Humana como em Medicina Veterinária, em neoplasias deste tipo histológico,
pela elevada eficácia e baixa toxicidade reportadas. O presente estudo pretendeu descrever e
avaliar, com base numa classificação adaptada do documento Common Terminology Criteria
for Adverse Events Following Chemotherapy or Biological Antineoplastic Therapy in Dogs
and Cats v1.0 (CTCAE) desenvolvido pelo Veterinary Co-operative Oncology Group
(VCOG) em 2004, os efeitos adversos associados a esta modalidade terapêutica numa amostra
de 17 gatos com CCE oral e cutâneo na região da cabeça submetidos a pelo menos uma
sessão de EQT. Verificou-se que todos os animais apresentaram efeitos adversos pelo menos
uma vez, sendo que a dor e a necrose estiveram presentes em 100% dos animais. As
toxicidades constitucional, respiratória e gastrointestinal também estiveram presentes em mais
de metade da amostra. As toxicidades observadas foram maioritariamente de grau II CTCAEVCOG.
Squamous cell carcinoma is a malignant neoplasm that originates in the squamous epithelium, which accounts for about 10% to 15% of cutaneous neoplasms and about 60 to 70% of oral neoplasms in cats. Electrochemotherapy is a therapeutic modality directed to cutaneous and subcutaneous neoplasms, which has gaining popularity in both Human and Veterinary Medicine, in tumors of this histological type, due to its high efficacy and low toxicity. The present study aims to describe and evaluate, based on a classification adapted from the Common Terminology Criteria for Adverse Events Following Chemotherapy or Biological Antineoplastic Therapy in Dogs and Cats v1.0 (CTCAE) developed by the Veterinary Cooperative Oncology Group (VCOG) in 2004, the adverse effects associated with this therapeutic modality in a sample of 17 cats with oral and cutaneous head squamous cell carcinoma, submitted to at least one electrochemotherapy session. All animals were found to have adverse effects at least once, with pain and necrosis being present in 100% of the animals. Constitutional, respiratory and gastrointestinal toxicity were also present in more than half of the sample. The toxicities observed were mostly grade II CTCAE-VCOG.
Squamous cell carcinoma is a malignant neoplasm that originates in the squamous epithelium, which accounts for about 10% to 15% of cutaneous neoplasms and about 60 to 70% of oral neoplasms in cats. Electrochemotherapy is a therapeutic modality directed to cutaneous and subcutaneous neoplasms, which has gaining popularity in both Human and Veterinary Medicine, in tumors of this histological type, due to its high efficacy and low toxicity. The present study aims to describe and evaluate, based on a classification adapted from the Common Terminology Criteria for Adverse Events Following Chemotherapy or Biological Antineoplastic Therapy in Dogs and Cats v1.0 (CTCAE) developed by the Veterinary Cooperative Oncology Group (VCOG) in 2004, the adverse effects associated with this therapeutic modality in a sample of 17 cats with oral and cutaneous head squamous cell carcinoma, submitted to at least one electrochemotherapy session. All animals were found to have adverse effects at least once, with pain and necrosis being present in 100% of the animals. Constitutional, respiratory and gastrointestinal toxicity were also present in more than half of the sample. The toxicities observed were mostly grade II CTCAE-VCOG.
Descrição
Orientação: Ana Faustino ; co-orientação: Ana Rita Serras
Palavras-chave
MESTRADO INTEGRADO EM MEDICINA VETERINÁRIA, VETERINÁRIA, MEDICINA VETERINÁRIA, EFEITOS SECUNDÁRIOS, FELÍDEOS, GATOS, VETERINARY MEDICINE, SIDE EFFECTS, FELIDS, CATS, ELETROQUIMIOTERAPIA, CARCINOMA DE CÉLULAS ESCAMOSAS, BLEOMICINA, ELECTROCHEMOTHERAPY, SQUAMOUS CELL CARCINOMA, BLEOMYCIN