Patogénese de infecções causadas por bactérias da flora endógena
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2013
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A flora microbiana humana cujos elementos major são bactérias, tem sido
caracterizada como uma componente essencial do corpo humano. A sua
importância baseia-se no seu envolvimento benéfico numa variedade de funções
metabólicas, imunitárias e antimicrobianas. Os resultados destas funções incluem a
homeostasia do organismo humano. Contudo, a flora microbiana humana tem sido
associada com o desenvolvimento de numerosas infecções denominadas por
infecções endógenas tais como as infecções orais. Estas infecções são comuns nos
hospedeiros comprometidos, o que contribui para o aumento do seu significado
clínico.
Nesta dissertação foi feita uma abordagem à patogénese bacteriana assim como
aos passos do processos infecciosos e aos factores de virulência. Foi também feita
a associação destes à susceptibilidade do hospedeiro com o propósito de
compreender os seus contributos para o desenvolvimento das infecções
endógenas. Por outro lado, foram exploradas algumas consequências sistémicas
infecciosas (endocardite infecciosa) e não infecciosas (aterosclerose) de infecções
orais causadas pela flora bacteriana oral.
Human flora, whose major elements are bacteria, has been characterized as an essential component of the human body. Their importance is based in their beneficial involvement in a variety of metabolic, immunological and antimicrobial functions. The results of these functions include homeostasis of the human body. Although, the human microbial flora has been associated with the development of numerous infections are called endogenous infections such as oral infections. These infections are common in the compromised hosts, this contribute to the increase of their clinical significance. In this dissertation, an approach to the bacterial pathogenesis was made as well as the steps for the infectious processes and virulence factors. It was also made an association of them with the host susceptibility whose purpose was to understand their contributes for development of endogenous infections. On the other hand, it was explored some the both infectious (infectivity endocarditis) and non-infectious (atherosclerosis) systemic consequences of oral infections caused by oral bacterial flora.
Human flora, whose major elements are bacteria, has been characterized as an essential component of the human body. Their importance is based in their beneficial involvement in a variety of metabolic, immunological and antimicrobial functions. The results of these functions include homeostasis of the human body. Although, the human microbial flora has been associated with the development of numerous infections are called endogenous infections such as oral infections. These infections are common in the compromised hosts, this contribute to the increase of their clinical significance. In this dissertation, an approach to the bacterial pathogenesis was made as well as the steps for the infectious processes and virulence factors. It was also made an association of them with the host susceptibility whose purpose was to understand their contributes for development of endogenous infections. On the other hand, it was explored some the both infectious (infectivity endocarditis) and non-infectious (atherosclerosis) systemic consequences of oral infections caused by oral bacterial flora.
Descrição
Orientador: Maria João Simões
Palavras-chave
INFEÇÕES, INFECTIONS, MESTRADO INTEGRADO EM CIÊNCIAS FARMACÊUTICAS, BACTÉRIAS, BACTERIA, CIÊNCIAS FARMACÊUTICAS, PHARMACEUTICAL SCIENCES