Quantifying myocardial fibrosis on murine model using ImageJ

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dc.contributor.authorCatarino, José Carlos Mota
dc.contributor.authorViegas, Inês
dc.contributor.authorRodrigues, Joana
dc.contributor.authorPinto, Marta
dc.contributor.authorBota, Gonçalo
dc.contributor.authorCravo, Francisco
dc.contributor.authorLúcio, Filipa
dc.contributor.authorFaísca, Pedro
dc.date.accessioned2019-04-08T16:20:52Z
dc.date.available2019-04-08T16:20:52Z
dc.date.issued2019
dc.descriptionRevista Lusófona de Ciência e Medicina Veterináriapt
dc.description.abstractQuantification of histological images is a task often required in biomedical research. Many of the methods used are time-consuming, difficult to replicate and subjective. This work aimed to describe and validate a more objective, reproducible and easy to perform methodology to measure murine heart fibrosis, using ImageJ software. For this matter, a macro was created and validated for its intra and inter-observational reproducibility. No significant differences were found between the results obtained manually and with the macro (p> 0.05). Regarding the interobserver variability, the macro proved to be a less variable method by presenting higher correlation coefficients between observers when compared with the manual measurement. With these results, we were able to define and describe a methodology that outputs objective and replicable results in a less laborious way.pt
dc.formatapplication/pdf
dc.identifier.urihttp://hdl.handle.net/10437/9490
dc.language.isoengpt
dc.publisherEdições Universitárias Lusófonaspt
dc.rightsopenAccess
dc.subjectIMAGEJpt
dc.subjectVETERINÁRIApt
dc.subjectMEDICINA VETERINÁRIApt
dc.subjectFIBROSEpt
dc.subjectCORAÇÃOpt
dc.subjectFIBROSISen
dc.subjectHEARTen
dc.subjectVETERINARY MEDICINEen
dc.subjectMORFOMETRIApt
dc.subjectMORPHOMETRYen
dc.subject
dc.subjectPATOLOGIA EXPERIMENTALpt
dc.subjectEXPERIMENTAL PATHOLOGYen
dc.titleQuantifying myocardial fibrosis on murine model using ImageJpt
dc.typearticlept

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Revista Lusófona de Ciência e Medicina Veterinária Vol. 09 (2018)