Uso terapêutico de quinolonas e avaliação dos padrões de consumo de antibióticos numa farmácia comunitária
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2021
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Desde o desenvolvimento dos antibióticos no século XX, a taxa de mortalidade associada a infeções bacterianas tem vindo a diminuir.
O aumento da utilização de antibióticos e o consumo irracional encontram-se diretamente relacionados com o aparecimento de resistências associadas aos antimicrobianos. Estas representam um problema de saúde pública nacional e global.
As quinolonas encontram-se entre os antibióticos mais associados ao desenvolvimento de resistências. Estas são antibióticos sintéticos, de amplo espetro bacteriano, que interferem na síntese de ADN. Atualmente, encontram-se restritos em termos de utilização, pelo Infarmed.
O presente documento foi elaborado no âmbito da unidade curricular “Estágio” do Mestrado Integrado em Ciências Farmacêuticas, para ser apresentado à Universidade Lusófona com vista à obtenção de grau de Mestre.
A monografia tem como objetivo a revisão bibliográfica da literatura das quinolonas, e o estudo empírico dos padrões de consumo dos antibióticos dos utentes da farmácia Silveira, através da análise descritiva dos resultados obtidos de um questionário.
Os resultados demonstraram um consumo reduzido de antibióticos, e um comportamento favorável em relação à compliance antimicrobiana, e à redução da taxa de resistências antimicrobianas. Este estudo demonstrou que o papel do farmacêutico comunitário não deve ser ignorado, pois os seus conselhos podem levar à consciencialização para o uso racional de antibióticos.
Since the development of antibiotics in the 20th century, the mortality rate associated to bacterial infections has been decreasing. The increased use of antibiotics and irrational consumption are directly related to the emergence of resistance associated with antimicrobials. They represent a public health problem nationally and globally. Quinolones are among the antibiotics most associated with the development of resistance. They are synthetic antibiotics with a broad bacterial spectrum that interfere with DNA synthesis. Currently, they are restricted in terms of use by the Infarmed. This document was elaborated within the scope of the curricular unit “Intership” of Integrated Master in Pharmaceutical Sciences, to be presented to the Universidade Lusófona aiming at obtaining a Master's degree. The objective of the monograph is a literature review of quinolones, and an empirical study of antibiotic consumption patterns of patients in the Silveira pharmacy, through descriptive analysis of the results obtained from a questionnaire. The results demonstrated a reduced consumption of antibiotics, and a favorable behavior in relation to antimicrobials compliance, and a reduction in the rate of antimicrobial resistance. This study demonstrated that the role of the community pharmacist should not be ignored, as their advice can lead to awareness of the rational use of antibiotics.
Since the development of antibiotics in the 20th century, the mortality rate associated to bacterial infections has been decreasing. The increased use of antibiotics and irrational consumption are directly related to the emergence of resistance associated with antimicrobials. They represent a public health problem nationally and globally. Quinolones are among the antibiotics most associated with the development of resistance. They are synthetic antibiotics with a broad bacterial spectrum that interfere with DNA synthesis. Currently, they are restricted in terms of use by the Infarmed. This document was elaborated within the scope of the curricular unit “Intership” of Integrated Master in Pharmaceutical Sciences, to be presented to the Universidade Lusófona aiming at obtaining a Master's degree. The objective of the monograph is a literature review of quinolones, and an empirical study of antibiotic consumption patterns of patients in the Silveira pharmacy, through descriptive analysis of the results obtained from a questionnaire. The results demonstrated a reduced consumption of antibiotics, and a favorable behavior in relation to antimicrobials compliance, and a reduction in the rate of antimicrobial resistance. This study demonstrated that the role of the community pharmacist should not be ignored, as their advice can lead to awareness of the rational use of antibiotics.
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Orientação: Ana Sofia Fernandes
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MESTRADO INTEGRADO EM CIÊNCIAS FARMACÊUTICAS, CIÊNCIAS FARMACÊUTICAS, ANTIBIÓTICOS, QUINOLONAS, CONSUMO DE ANTIBIÓTICOS, RESISTÊNCIA AOS ANTIBIÓTICOS, PHARMACEUTICAL SCIENCES, ANTIBIOTICS, QUINOLONES, ANTIBIOTIC CONSUMPTION, ANTIMICROBIAL RESISTANCE, ANTIMICROBIAL RESISTANCE