Estudo preliminar da eficácia analgésica da administração de bupivacaína intraperitoneal em ovariohisterectomias eletivas em coelhas (oryctolagus cuniculus)
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2023
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Actualmente, a preocupação e o interesse dos veterinários pela dor pós-operatória está a tornar-se cada vez mais notória. A ovariohisterectomia eletiva é um exemplo de intervenção cirúrgica e um procedimento de rotina em coelhos. Resulta num nível moderado de dor aguda, exigindo um tratamento analgésico adequado e eficaz. Este estudo visou avaliar a eficácia analgésica pós-operatória da administração intraperitoneal de bupivacaína em coelhas submetidas a ovariohisterectomia eletiva. Neste estudo foram incluídas catorze coelhas fêmeas (n=14) que seriam submetidas a ovarioesterectomia electiva, as quais foram posteriormente divididas aleatoriamente em dois grupos (n=7 por grupo). O protocolo anestésico de ambos consistia em dexmedetomidina, butorfanol e midazolam como pré-medicação, propofol para indução, isoflurano para manutenção e quando necessário, resgate analgésico intracirúrgico com fentanil. Um grupo recebeu 2 mg/kg de bupivacaína intraperitoneal e solução salina para completar um volume de 3 ml, e o outro grupo recebeu 3 ml de solução salina. Para avaliar a dor pós-operatória foram utilizadas a Escala de Dor de Coelho Bristol (BRPS) e a Escala Multidimensional de Dor Composta para Coelho (CANCRS), foram também registados os tempos até à primeira defecação e até à primeira ingestão alimentar. Com o presente estudo não foi possível afirmar que esta técnica anestésica local beneficia a analgesia pós-operatória em coelhas fêmeas submetidas a ovarioesterectomia electiva, uma vez que não houve diferença estatisticamente significativa entre os dois grupos. Serão necessários mais estudos com um maior número de sujeitos para avaliar a eficácia analgésica desta técnica anestésica local em ovarioesterectomias eletivas em coelhas fêmeas. Palavras-chave: anestesia; ovariohisterectomia; dor; bupivacaina; intraperitoneal
Nowadays, the concern and interest of veterinarians for postoperative pain are becoming more and more notorious. Elective ovariohysterectomy is an example of surgical intervention and a routine procedure in rabbits. It results in a moderate level of acute pain, requiring adequate and effective analgesic treatment. This study aimed to evaluate the postoperative analgesic efficacy of intraperitoneal bupivacaine administration in female rabbits submitted to elective ovariohysterectomy. Fourteen female rabbits (n=14) that were to undergo elective ovariohysterectomy were included in this study and were subsequently randomly divided into two groups (n=7 per group). The anesthetic protocol of both consisted of dexmedetomidine, butorphanol and midazolam as premedication, propofol for induction, isoflurane for maintenance and when necessary intracirurgical analgesic rescue with fentanyl. One group received 2 mg/kg bupivacaine intraperitoneal and saline solution to complete a volume of 3 ml, and the other group received 3 ml saline solution. To assess postoperative pain the Bristol Rabbit Pain Scale (BRPS) and the Multidimensional Composite Pain Scale for Rabbit (CANCRS) were used and the times to first defecation and first food intake were also recorded. With the present study it was not possible to state that this local anaesthesia technique benefits postoperative analgesia in female rabbits undergoing elective ovariohysterectomy, as there was no statistically significant difference between the two groups. Further studies with a larger number of subjects will be necessary to evaluate the analgesic efficacy of this local anaesthesia technique in elective ovariohysterectomies in female rabbits. Keyword: anesthesia; ovariohysterectomy; pain; bupivacaine; intraperitoneal
Nowadays, the concern and interest of veterinarians for postoperative pain are becoming more and more notorious. Elective ovariohysterectomy is an example of surgical intervention and a routine procedure in rabbits. It results in a moderate level of acute pain, requiring adequate and effective analgesic treatment. This study aimed to evaluate the postoperative analgesic efficacy of intraperitoneal bupivacaine administration in female rabbits submitted to elective ovariohysterectomy. Fourteen female rabbits (n=14) that were to undergo elective ovariohysterectomy were included in this study and were subsequently randomly divided into two groups (n=7 per group). The anesthetic protocol of both consisted of dexmedetomidine, butorphanol and midazolam as premedication, propofol for induction, isoflurane for maintenance and when necessary intracirurgical analgesic rescue with fentanyl. One group received 2 mg/kg bupivacaine intraperitoneal and saline solution to complete a volume of 3 ml, and the other group received 3 ml saline solution. To assess postoperative pain the Bristol Rabbit Pain Scale (BRPS) and the Multidimensional Composite Pain Scale for Rabbit (CANCRS) were used and the times to first defecation and first food intake were also recorded. With the present study it was not possible to state that this local anaesthesia technique benefits postoperative analgesia in female rabbits undergoing elective ovariohysterectomy, as there was no statistically significant difference between the two groups. Further studies with a larger number of subjects will be necessary to evaluate the analgesic efficacy of this local anaesthesia technique in elective ovariohysterectomies in female rabbits. Keyword: anesthesia; ovariohysterectomy; pain; bupivacaine; intraperitoneal
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Orientação: Lénio Bruno Martins Ribeiro ; coorientação: Rui Filipe Galinho Patrício
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VETERINÁRIA, MEDICINA VETERINÁRIA, VETERINARY MEDICINE, OVARIOHISTERECTOMIA, OVARIOHYSTERECTOMY, DOR, PAIN, COELHOS, RABBITS, MESTRADO INTEGRADO EM MEDICINA VETERINÁRIA, ANESTESIA VETERINÁRIA, VETERINARY ANAESTHESIA