Abordagem à mielopatia degenerativa com a utilização de células estaminais
Miniatura indisponível
Data
2023
Título da revista
ISSN da revista
Título do Volume
Editora
Resumo
A mielopatia degenerativa (MD) é uma doença neurodegenerativa em cães, de idade média a avançada. Os sinais clínicos são desde ataxia propriocetiva a paraparésia não ambulatória assimétrica.
O objetivo foi avaliar a importância de protocolos de neuroreabilitação funcional intensivos (PNRFI) associados à administração de células estaminais (CE) no tempo de sobrevivência e qualidade de vida dos doentes. Foram incluídos 18 cães com diagnóstico por exclusão de MD, 11 constituíram o grupo de estudo (GE) e 7 o grupo de controlo (GC). No GE, os cães foram submetidos a PNRFI+CE, enquanto no GC a PNRF. Os protocolos incluíram electroestimulação e treino locomotor.
A amostra foi de 12 machos e 6 fêmeas, com idade média de 10,44 anos, peso médio de 31,56 kg e 10 cães possuíam genótipo heterozigótico e 8 homozigótico.
Os resultados demonstraram que PNRFI+CE, prolongam o tempo médio de vida, em cerca de 13 meses (396 dias). No GE foi observado 55% de sobrevivência no tempo ≥ 1 ano. Enquanto no GC, 100% em < 1 ano, sendo a comparação entre grupos representada em X2 (2, n=18)=0,057. No GE o último follow up com o teste genético obteve significância de X2(2, n=11)=0,022, pois os homozigóticos têm pior prognóstico.
Em conclusão, a implementação de PNRFI+CE evidenciou ser possível terapêutica.
Estudos futuros serão necessários.
Palavras-chave: cães, células estaminais, mielopatia degenerativa, protocolos de neuroreabilitação funcional intensivos, tempo médio de vida
Degenerative myelopathy (DM) is a neurodegenerative disease in dogs of middle to advanced age. Clinical signs range from proprioceptive ataxia to asymmetrical non-ambulatory paraparesis. The objective was to evaluate the importance of intensive functional neurorehabilitation protocols (PNRFI) associated with the administration of stem cells (SC) in the survival time and quality of life of patients. Eighteen dogs diagnosed by exclusion of DM were included, 11 constituted the study group (SG) and 7 the control group (CG). In the SG, the dogs were submitted to PNRFI+SC, while in the CG, the PNRF. Protocols included electrostimulation and locomotor training. The sample consisted of 12 males and 6 females, with a mean age of 10.44 years, mean weight of 31.56 kg and 10 dogs had heterozygous and 8 homozygous genotypes. The results showed that PNRFI+SC prolongs the average life span by about 13 months (396 days). In the SG, 55% survival was observed in time ≥ 1 year. While in the CG, 100% in < 1 year, with the comparison between groups represented in X2 (2, n=18)=0.057. In the SG, the last follow-up with the genetic test obtained a significance of X2(2, n=11)=0.022, as homozygotes have a worse prognosis. In conclusion, the implementation of PNRFI+SC proved to be a possible therapy. Future studies will be needed. Key words: dogs, stem cells, degenerative myelopathy, intensive functional neurorehabilitation protocols, mean life span
Degenerative myelopathy (DM) is a neurodegenerative disease in dogs of middle to advanced age. Clinical signs range from proprioceptive ataxia to asymmetrical non-ambulatory paraparesis. The objective was to evaluate the importance of intensive functional neurorehabilitation protocols (PNRFI) associated with the administration of stem cells (SC) in the survival time and quality of life of patients. Eighteen dogs diagnosed by exclusion of DM were included, 11 constituted the study group (SG) and 7 the control group (CG). In the SG, the dogs were submitted to PNRFI+SC, while in the CG, the PNRF. Protocols included electrostimulation and locomotor training. The sample consisted of 12 males and 6 females, with a mean age of 10.44 years, mean weight of 31.56 kg and 10 dogs had heterozygous and 8 homozygous genotypes. The results showed that PNRFI+SC prolongs the average life span by about 13 months (396 days). In the SG, 55% survival was observed in time ≥ 1 year. While in the CG, 100% in < 1 year, with the comparison between groups represented in X2 (2, n=18)=0.057. In the SG, the last follow-up with the genetic test obtained a significance of X2(2, n=11)=0.022, as homozygotes have a worse prognosis. In conclusion, the implementation of PNRFI+SC proved to be a possible therapy. Future studies will be needed. Key words: dogs, stem cells, degenerative myelopathy, intensive functional neurorehabilitation protocols, mean life span
Descrição
Orientação: Lénio Ribeiro ; coorientação: Ângela Martins
Palavras-chave
MESTRADO INTEGRADO EM MEDICINA VETERINÁRIA, MEDICINA VETERINÁRIA, VETERINARY MEDICINE, VETERINÁRIA, CANÍDEOS, CANIDS, CÃES, DOGS, CÉLULAS ESTAMINAIS, STEM CELLS, MIELOPATIA DEGENERATIVA, DEGENERATIVE MYELOPATHY, REABILITAÇÃO FUNCIONAL, FUNCTIONAL REHABILITATION