The update of semantic memories in amnestic Mild Cognitive Impairment

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dc.contributor.authorMendonça, Alexandre de
dc.contributor.authorCardoso, Sandra
dc.contributor.authorMaroco, João
dc.contributor.authorGuerreiro, Manuela
dc.contributor.authorCarmo, Joana Costa
dc.date.accessioned2024-02-29T09:42:01Z
dc.date.available2024-02-29T09:42:01Z
dc.date.issued2021
dc.descriptionJournal of Neuropsychologyen
dc.description.abstractIt is still controversial to what extent neocortical consolidated memories are susceptible of change by processes of reconsolidation and transformation throughout experience, and whether the medial temporal lobes are necessary for this update of semantic consolidated memories, as they are for episodic remembering. We hypothesise that patients with amnestic mild cognitive impairment (aMCI) who have deficits in episodic memory may also have difficulties in updating information on added new features of objects. Sixteen participants with aMCI and 20 healthy control participants performed a semantic Word-to-Picture task, in which they were asked to identify as belonging to a given semantic category NEW objects, that have incorporated novel features, as well as OLD items, semantically and visually SIMILAR items and UNRELATED items. Patients with aMCI made a greater percentage of errors than healthy controls. Participants globally made greater percentages of errors in difficult types of items, namely NEW and SIMILAR, as compared to easier ones, OLD and UNRELATED. Importantly, an item by diagnostic group interaction effect was observed, and post hoc analysis showed that patients with aMCI made a higher percentage of errors than controls in NEW items only. In conclusion, patients with aMCI had a particular difficulty in identifying the NEW items of the Word-to-Picture task as compared to the control participants, supporting the concept of a flexible and dynamic conceptual knowledge system, involving the update of semantic memories and the integration of new attributes in a constant transformation process, which is impaired in these patients. Keywords: Mild Cognitive Impairment; memory transformation account; semantic system; semantic updatept
dc.description.sponsorshipThe present work was financed by national funding through FCT – Fundação para a Ciência e a Tecnologia, I. P., on the scope of Norma Transitória DL57/2016/CP1439/CT02. The funders had no role in study design, data collection and analysis, or preparation of the manuscriptpt
dc.formatapplication/msword
dc.identifier.citationde Mendonça A, Cardoso S, Maroco J, Guerreiro M, Carmo JC. The update of semantic memories in amnestic mild cognitive impairment. Journal of Neuropsycholy. 2021 Apr;15 Suppl 1:27-40. doi: 10.1111/jnp.12217.pt
dc.identifier.issn1748-6653
dc.identifier.urihttp://hdl.handle.net/10437/14536
dc.language.isoeng
dc.publisherWileypt
dc.rightsopenAccesspt
dc.subjectDÉFICE COGNITIVO LIGEIROpt
dc.subjectMILD COGNITIVE IMPAIRMENTpt
dc.subjectMEMÓRIA SEMÂNTICApt
dc.subjectSEMANTIC MEMORYen
dc.subjectMEMÓRIApt
dc.subjectMEMORYen
dc.subjectNEUROPSICOLOGIApt
dc.subjectNEUROPSYCHOLOGYen
dc.titleThe update of semantic memories in amnestic Mild Cognitive Impairmenten
dc.typearticle

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