O efeito de diferentes tipos de exercício sobre o conteúdo e/ou expressão genética da PGC-1 no vastos lateral em humanos: uma revisão sistemática
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2022
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Introdução: O exercício físico é apontado como um potente estimulador da biogénese mitocondrial. Adicionalmente, tem sido descrito que diferentes tipos de exercício têm impactos distintos na biogénese mitocondrial. Contudo, do nosso conhecimento, não existe uma revisão sistemática sobre o efeito de diferentes tipos de exercício (contínuo, intervalado, de força e combinado ou misto) no conteúdo e /ou expressão genética da PGC-1α, um dos principais intervenientes no processo de biogénese mitocondrial.
Objetivos: Verificar e analisar o potencial impacto de diferentes tipos de treino sobre o conteúdo PGC-1α e/ou da sua expressão genética em humanos, através de uma revisão sistemática da literatura.
Metodologia: Foi realizada uma revisão sistemática de acordo com as diretrizes do PRISMA (Preferred Reporting Items for Systematic Reviews and Meta – Analyses). A pesquisa de ensaios controlados randomizados foi efetuada nas bases de dados científicas da área da saúde, nomeadamente a MEDLINE utilizando como interface a PubMed. Foram utilizados critérios de pesquisa visando artigos publicados entre 2000 e 2020 sobre os efeitos de diferentes tipos de exercício no conteúdo e ou expressão genética da PGC1 α no vastos lateral de humanos. A lista de artigos foi posteriormente refinada usando critérios específicos de inclusão e exclusão. Foi estimada a qualidade metodológica e potencial risco de viés usando RoB-2 (Cochrane risk-of-bias tool).
Resultados: Foram incluídos 22 estudos. Os programas de exercício (agudos e crónicos) dividiram-se em exercício continuo, intervalado, de força e combinado. Foram reportados aumentos significativos do conteúdo e ou expressão genética da PGC-1α: i) em 81% dos estudos com exercício contínuo; ii) 100% dos estudos com exercício intervalado; iii) 40% dos estudos com exercício de força; i) 100% dos estudos com exercício combinado.
Conclusão: Os resultados sugerem que o exercício continuo, intervalado e combinado parecem ser eficazes no aumento do conteúdo e/ou expressão genética da PGC-1α.
Palavras chave: Vasto lateral; biogénese mitocondrial; exercício físico; treino; PGC-1 α
Introduction: Physical exercise has been considered a potent stimulator of mitochondrial biogenesis. Additionally, different types of exercise have been reported to have different impacts on mitochondrial biogenesis. However, to our knowledge, there is no systematic review on the effect of different types of exercise (continuous, interval, strength and combined or mixed) on the content and/or gene expression of PGC-1α, one of the main players in the process of mitochondrial biogenesis. Aims: To verify and analyze the potential impact of different types of training on PGC-1α content and/or its gene expression in humans, through a systematic literature review. Methodology A systematic review was performed according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta – Analyzes) guidelines. The search for randomized controlled trials was carried out in scientific databases in the health area, namely MEDLINE, using PubMed as an interface. Search criteria were used targeting articles published between 2000 and 2020 on the effects of different types of exercise on the content and/or gene expression of PGC-1α in the vastus lateralis of humans. The list of articles was further refined using specific inclusion and exclusion criteria. Methodological quality and potential risk of bias were estimated using RoB-2 (Cochrane risk-of-bias tool). Resulted: 22 studies were included. The exercise programs (acute and chronic) were divided into continuous, interval, strength and combined exercise. Significant increases in PGC-1α content and/or gene expression were reported: i) in 81% of studies with continuous exercise; ii) 100% of studies with interval exercise; iii) 40% of the studies with strength exercise; i) 100% of studies with combined exercise. Conclusion: The results suggest that continuous, interval and combined exercise seem to be effective in increasing the content and/or gene expression of PGC-1α. Key-words: Vastus lateralis; mitochondrial biogenesis; physical exercise; training; PGC-1α
Introduction: Physical exercise has been considered a potent stimulator of mitochondrial biogenesis. Additionally, different types of exercise have been reported to have different impacts on mitochondrial biogenesis. However, to our knowledge, there is no systematic review on the effect of different types of exercise (continuous, interval, strength and combined or mixed) on the content and/or gene expression of PGC-1α, one of the main players in the process of mitochondrial biogenesis. Aims: To verify and analyze the potential impact of different types of training on PGC-1α content and/or its gene expression in humans, through a systematic literature review. Methodology A systematic review was performed according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta – Analyzes) guidelines. The search for randomized controlled trials was carried out in scientific databases in the health area, namely MEDLINE, using PubMed as an interface. Search criteria were used targeting articles published between 2000 and 2020 on the effects of different types of exercise on the content and/or gene expression of PGC-1α in the vastus lateralis of humans. The list of articles was further refined using specific inclusion and exclusion criteria. Methodological quality and potential risk of bias were estimated using RoB-2 (Cochrane risk-of-bias tool). Resulted: 22 studies were included. The exercise programs (acute and chronic) were divided into continuous, interval, strength and combined exercise. Significant increases in PGC-1α content and/or gene expression were reported: i) in 81% of studies with continuous exercise; ii) 100% of studies with interval exercise; iii) 40% of the studies with strength exercise; i) 100% of studies with combined exercise. Conclusion: The results suggest that continuous, interval and combined exercise seem to be effective in increasing the content and/or gene expression of PGC-1α. Key-words: Vastus lateralis; mitochondrial biogenesis; physical exercise; training; PGC-1α
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Orientação: Inês Marques Aleixo
Palavras-chave
MESTRADO EM EXERCÍCIO E SAÚDE, EXERCÍCIO FÍSICO, PHYSICAL EXERCISE, REVISÃO BIBLIOGRÁFICA, BIBLIOGRAPHIC REVIEW, BIOGÉNESE MITOCONDRIAL, MITOCHONDRIAL BIOGENESIS