Avaliação da aplicabilidade da proposta de graduação de kiupel dos mastocitomas cutâneos em cães
Miniatura indisponível
Ficheiros
Data
2013
Autores
Título da revista
ISSN da revista
Título do Volume
Editora
Resumo
O mastocitoma é o tumor de pele mais comum em cães e caracteriza-se pela
proliferação de mastócitos tumorais. O diagnóstico mais assertivo da doença faz-se através
da análise histopatológica. Esta permite a classificação da neoplasia em diferentes graus
conferindo um importante critério preditivo do comportamento biológico e tratamento da
neoplasia. Várias classificações têm sido propostas ao longo do tempo, contudo, baseiamse
em parâmetros subjetivos provocando variações consideráveis entre observadores,
limitando assim o valor de prognóstico. Para colmatar este dado, Kiupel et al., (2011) propôs
um sistema histológico para a classificação de mastocitomas em cães de apenas dois graus.
A avaliação desta nova proposta e a comparação com a escala mais antiga,
proposta por Patnaik et al., (1984) foi o objetivo principal deste estudo. Deste modo, foram
reclassificados vinte mastocitomas caninos. O seguimento de cada caso ao longo de sete a
dez meses foi feito através de um questionário entregue às clinicas.
Dos vinte cães em estudo e classificados segundo a escala proposta por Patnaik et
al., (1984) 65% correspondiam a tumores de grau II, sendo os mais frequentes. Seguiram-se
os de grau III (30%) e os de grau I (5%). Na reclassificação, utilizando a escala proposta por
Kiupel et al., (2011), o grau II foi o mais frequente correspondendo a 55% dos casos e o
grau I a 45%. Na escala de Patnaik et al.,(1984), as recidivas ocorreram no grau III com 67%
dos casos. Na escala de Kiupel et al.,(2011), as recidivas ocorreram em 36% dos casos de
grau II. Estes números evidenciam um prognóstico mais correto para os tumores
classificados com grau III segundo Patnaik et al.,(1984) do que os de grau II segundo Kiupel
et al., (2011).
Assim, parece que a nova proposta de classificação não acrescenta grande valor
prognóstico.No entanto, o presente estudo não avaliou a amostra no mesmo intervalo de
tempo e a mesma também variou no que diz respeito ao número de animais em estudo,
sendo que estes dados poderam ter condicionado o presente estudo e as suas conclusões.
Mast cell tumor is the most common skin neoplasm in dogs and is characterized by a proliferation of neoplastic mast cells. The diagnosis is more assertive by histopathology, which allows the classification in different grades, with different biological behaviors and treatment protocols. Several classifications have been proposed, but because of their subjective basis, there are substantial fluctuations interobservers, limiting its prognostic value. To overcome this fact, Kiupel et al., (2011) proposed a system with only two histological grades. The main objective of this study was to evaluate this new proposal and compare it with an older one proposed by Patnaik et al., (1984). Twenty canine mast cell tumors were graded by both methods. 65% were classified as grade II, 30% as grade III and 5% as grade I according to Patnaik et al., (1984). Following the assumptions of Kiupel et al., (2011), 55% were classified as grade II and 45% as grade I. With the Patnaik’s grading system, recurrence occurred in 67% of cases with grade III, while with the Kiupel’s grading system, recurrence occurred in 36% of the grade II cases. These numbers show a more accurate prognosis for tumors classified as grade III by Patnaik et al., (1984) than by Kiupel’s grade II. These results suggest that the new classification doesn’t add higher prognostic value to mast cell tumors. However, this study did not evaluatethe samplein the same range of time andalso variedin respect to the numberof animals inthe study, andthese datahaveconditionedthis studyand conclusions.
Mast cell tumor is the most common skin neoplasm in dogs and is characterized by a proliferation of neoplastic mast cells. The diagnosis is more assertive by histopathology, which allows the classification in different grades, with different biological behaviors and treatment protocols. Several classifications have been proposed, but because of their subjective basis, there are substantial fluctuations interobservers, limiting its prognostic value. To overcome this fact, Kiupel et al., (2011) proposed a system with only two histological grades. The main objective of this study was to evaluate this new proposal and compare it with an older one proposed by Patnaik et al., (1984). Twenty canine mast cell tumors were graded by both methods. 65% were classified as grade II, 30% as grade III and 5% as grade I according to Patnaik et al., (1984). Following the assumptions of Kiupel et al., (2011), 55% were classified as grade II and 45% as grade I. With the Patnaik’s grading system, recurrence occurred in 67% of cases with grade III, while with the Kiupel’s grading system, recurrence occurred in 36% of the grade II cases. These numbers show a more accurate prognosis for tumors classified as grade III by Patnaik et al., (1984) than by Kiupel’s grade II. These results suggest that the new classification doesn’t add higher prognostic value to mast cell tumors. However, this study did not evaluatethe samplein the same range of time andalso variedin respect to the numberof animals inthe study, andthese datahaveconditionedthis studyand conclusions.
Descrição
Orientação: Pedro Faísca ;
co-orientação: Alexandra Pereira
Palavras-chave
VETERINÁRIA, CANÍDEOS, NEOPLASIAS, MASTOCITOMAS, CANIDS, NEOPLASMS, MAST CELL TUMOR, MESTRADO INTEGRADO EM MEDICINA VETERINÁRIA, CÃES, DOGS, HISTOLOGIA VETERINÁRIA, VETERINARY HISTOLOGY, MEDICINA VETERINÁRIA, VETERINARY MEDICINE