Biomarcadores de doença renal crónica e a sua relação com um instrumento de qualidade de vida nos gatos
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Data
2021
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Resumo
Atualmente a avaliação da qualidade de vida tem-se demonstrado cada vez mais
importante no maneio de doenças crónicas, uma vez que apresentam um impacto negativo
na vida dos pacientes. Em gatos, a doença renal crónica constitui a nefropatia mais comum e
a principal causa de morte em idades superiores a cinco anos inclusive.
O presente estudo pretendeu avaliar sobretudo a relação entre os biomarcadores de
doença renal crónica e um instrumento de qualidade de vida em gatos. Para tal, contemplou
um total de 37 pacientes e recorreu-se ao único questionário validado para esta doença, o
CatQoL, que os tutores preencheram aquando das reavaliações do seu animal. Ao contrário
do (subestadio) rácio proteína/creatinina urinário, as variáveis creatinina sérica (rs = -.44),
estadio (rs = .36), (subestadio) pressão arterial sistólica (rs = .28 / -.24), ureia nitrogenada no
sangue, (rs = -.41), hematócrito (rs = .43), densidade urinária (rs = .37), fósforo (rs = -.43),
potássio (rs = -.57) e sódio (rs = -.56) apresentaram uma correlação estatisticamente
significativa com a qualidade de vida (p < 0,05).
Os resultados obtidos demonstraram que é possível recorrer à qualidade de vida para
aferir alterações nos biomarcadores estudados, promovendo assim a otimização do maneio
clínico destes pacientes sobretudo em situações em que a sua medição não é possível.
The assessment of quality of life has been shown to be increasingly important in the management of chronic diseases, as they have a negative impact on patients’ lives. In cats, chronic kidney disease is the most common nephropathy and the leading cause of death over the age of five years inclusive. The present study aimed to evaluate mainly the relationship between biomarkers of chronic kidney disease and a quality of life scale in cats. A total of 37 participants were include in the study that use a validated scale for quality of life in this disease, the CatQoL, which the owners filled out every time their animal was re-evaluated. Except the (substage) urine protein/creatinine ratio, the variables serum creatinine (rs = -.44), stage (rs = .36), (substage) systolic blood pressure (rs = .28 / -.24), urea, (rs = -.41), hematocrit (rs = .43), urine specific gravity (rs = .37), phosphorus (rs = -.43), potassium (rs = -.57) and sodium (rs = -.56) showed a statistically significant correlation with quality of life (p < 0,05). These results revealed that it is possible to use quality of life to measure changes in the biomarkers studied, thus promoting the optimization of the clinical management of these patients, especially in situations where its measurement is not possible.
The assessment of quality of life has been shown to be increasingly important in the management of chronic diseases, as they have a negative impact on patients’ lives. In cats, chronic kidney disease is the most common nephropathy and the leading cause of death over the age of five years inclusive. The present study aimed to evaluate mainly the relationship between biomarkers of chronic kidney disease and a quality of life scale in cats. A total of 37 participants were include in the study that use a validated scale for quality of life in this disease, the CatQoL, which the owners filled out every time their animal was re-evaluated. Except the (substage) urine protein/creatinine ratio, the variables serum creatinine (rs = -.44), stage (rs = .36), (substage) systolic blood pressure (rs = .28 / -.24), urea, (rs = -.41), hematocrit (rs = .43), urine specific gravity (rs = .37), phosphorus (rs = -.43), potassium (rs = -.57) and sodium (rs = -.56) showed a statistically significant correlation with quality of life (p < 0,05). These results revealed that it is possible to use quality of life to measure changes in the biomarkers studied, thus promoting the optimization of the clinical management of these patients, especially in situations where its measurement is not possible.
Descrição
Orientação: Rute Teixeira ; coorientação: Pedro Almeida
Palavras-chave
MESTRADO INTEGRADO EM MEDICINA VETERINÁRIA, MEDICINA VETERINÁRIA, VETERINÁRIA, FELÍDEOS, GATOS, DOENÇAS RENAIS, DOENÇAS CRÓNICAS, QUALIDADE DE VIDA, BIOMARCADORES, VETERINARY MEDICINE, FELIDS, CATS, KIDNEY DISEASES, CHRONIC DISEASES, QUALITY OF LIFE, BIOMARKERS