Características de sobrevivência de cães com doença mixomatosa valvular mitral
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2015
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A doença Mixomatosa Valvular Mitral (DMVM) é a doença cardíaca adquirida mais frequentemente diagnosticada em cães adultos. Uma vez que o curso desta doença é algo
imprevisível, é de grande importância clínica conseguir prever a sua progressão e a
longevidade de cães afectados.
Com este estudo pretendeu-se estimar o tempo de sobrevivência e o tempo até desenvolvimento de insuficiência cardíaca congestiva (ICC) numa amostra heterogenia de
cães, em diferentes estadios da doença. Adicionalmente foi avaliado o valor prognóstico de
determinados parâmetros ecocardiográficos em relação à sobrevida.
Foram utilizados historiais clínicos de 542 cães com DMVM, diagnosticados através de
ecocardiografia no Hospital Veterinário do Porto. A informação relativa à evolução clínica destes cães foi obtida através de entrevista telefónica.
Cento e vinte e seis de 241 (52.7%) cães morreram durante o período de observação (20.59
meses). O tempo médio de sobrevivência quando consideradas todas as causas de morte foi de 19.87 meses. Quando consideradas apenas as mortes devido à doença, o tempo médio de sobrevivência foi de 18.73 meses. O aumento da Emax (p= 0.049), do ETdec, (p= 0.026) e do EDDI (p= 0.008) demonstraram influenciar negativamente o tempo de sobrevivência destes cães. Quinze dos 150 (10%) cães assintomáticos reavaliados, desenvolveram ICC durante o período de observação. O tempo médio até desenvolvimento de ICC foi de 19.9 meses.
A DMVM ligeira a moderada representa uma doença relativamente benigna em cães. A
utilização de parâmetros ecocardiográficos poderá auxiliar na identificação de cães com um
pior prognóstico.
Myxomatous Mitral Valve Disease (MMVD) is the most commonly diagnosed acquired heart disease in adult dogs. Since the course of this disease is quite unpredictable, it is of clinical importance to be able to predict its progression and longevity of affected dogs. The aims of this study were to evaluate survival time and time until development of congestive heart failure (CHF) in a heterogeneous group of dogs, at varying stages of the disease. In addition, the prognostic value of certain echocardiographic parameters on survival was evaluated. Medical records of 542 dogs with MMVD, diagnosed by echocardiography at Hospital Veterinário do Porto, were reviewed. The information regarding long-term outcome of these dogs was obtained through telephone interviews. One hundred and twenty six of 241 (52.7%) dogs died during the observation period (20.59 months). The mean survival time, when all causes of death were considered, was 19.87 months. When only deaths due to the disease were considered, the mean survival time was 18.73 months. An increase in Emax (p= 0.049), in ETdec (p= 0.026) and in EDDI (p= 0.008), showed a negative effect on survival time of these dogs. Fifteen of the 150 (10%) asymptomatic dogs re-examined, developed CHF during the observation period. The mean time until development of CHF was 19.9 months. Mild to moderate MMVD represents a relatively benign disease in dogs. The use of echocardiographic parameters can help identify dogs with a worse prognosis.
Myxomatous Mitral Valve Disease (MMVD) is the most commonly diagnosed acquired heart disease in adult dogs. Since the course of this disease is quite unpredictable, it is of clinical importance to be able to predict its progression and longevity of affected dogs. The aims of this study were to evaluate survival time and time until development of congestive heart failure (CHF) in a heterogeneous group of dogs, at varying stages of the disease. In addition, the prognostic value of certain echocardiographic parameters on survival was evaluated. Medical records of 542 dogs with MMVD, diagnosed by echocardiography at Hospital Veterinário do Porto, were reviewed. The information regarding long-term outcome of these dogs was obtained through telephone interviews. One hundred and twenty six of 241 (52.7%) dogs died during the observation period (20.59 months). The mean survival time, when all causes of death were considered, was 19.87 months. When only deaths due to the disease were considered, the mean survival time was 18.73 months. An increase in Emax (p= 0.049), in ETdec (p= 0.026) and in EDDI (p= 0.008), showed a negative effect on survival time of these dogs. Fifteen of the 150 (10%) asymptomatic dogs re-examined, developed CHF during the observation period. The mean time until development of CHF was 19.9 months. Mild to moderate MMVD represents a relatively benign disease in dogs. The use of echocardiographic parameters can help identify dogs with a worse prognosis.
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Orientação : Luís Lima Lobo
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MESTRADO INTEGRADO EM MEDICINA VETERINÁRIA, CÃES, DOGS, INSUFICIÊNCIA CARDÍACA, HEART FAILURE, CANÍDEOS, CANIDS, ECOCARDIOGRAFIA, ECHOCARDIOGRAPHY, DOENÇA DEGENERATIVA MIXOMATOSA DA VÁLVULA MITRAL, MYXOMATOUS MITRAL VALVE DEGENERATION, PROGNÓSTICOS, PROGNOSIS, ANÁLISE DE SOBREVIVÊNCIA, SURVIVAL ANALYSIS, MEDICINA VETERINÁRIA, VETERINARY MEDICINE, VETERINÁRIA