Quantifying hepatic fibrosis on murine models: how to obtain representative results in a less laborious way

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dc.contributor.authorCatarino, José Carlos Mota
dc.contributor.authorViegas, Inês
dc.contributor.authorRodrigues, Joana
dc.contributor.authorPinto, Marta
dc.contributor.authorFaísca, Pedro
dc.date.accessioned2019-04-09T13:23:43Z
dc.date.available2019-04-09T13:23:43Z
dc.date.issued2019
dc.descriptionRevista Lusófona de Ciência e Medicina Veterináriapt
dc.description.abstractIn biomedical research, quantification of histological images is often required. Many of the methods used are time-consuming, laborious, originate variable results and are difficult to replicate. This paper is aimed towards finding a more objective, reproducible and easy to perform method to obtain representative results in murine models of hepatic fibrosis using ImageJ software. To do so on a liver fibrosis model, the percentages of fibrotic lesion obtained in an entire section and in several different magnifications were compared. No statistically significant differences were found (p> 0.05), but the correlation was stronger between the results obtained in the entire section photograph and the two photographs at 40x (r = 0.963). Using ImageJ facilitated the definition of a methodology that originated representative results on a liver section and at the same time allowed objective measurement in a reproducible and less laborious way.pt
dc.formatapplication/pdf
dc.identifier.urihttp://hdl.handle.net/10437/9492
dc.language.isoengpt
dc.publisherEdições Universitárias Lusófonaspt
dc.rightsopenAccess
dc.subjectIMAGEJpt
dc.subjectVETERINÁRIApt
dc.subjectMEDICINA VETERINÁRIApt
dc.subjectFIBROSEpt
dc.subjectFÍGADOpt
dc.subjectMORFOMETRIApt
dc.subjectVETERINARY MEDICINEen
dc.subjectFIBROSISen
dc.subjectLIVERen
dc.subjectMORPHOMETRYen
dc.subjectPATOLOGIA EXPERIMENTALpt
dc.subjectEXPERIMENTAL PATHOLOGYen
dc.titleQuantifying hepatic fibrosis on murine models: how to obtain representative results in a less laborious waypt
dc.typearticlept

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Revista Lusófona de Ciência e Medicina Veterinária Vol. 09 (2018)