Prevalência da hepatopatia associada ao cobre em cães num laboratório de referência em Portugal
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2022
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O cobre e um composto fundamental de muitas enzimas envolvidas em vários processos biológicos vitais. Apesar do cobre ser um componente intrínseco de diferentes proteínas essenciais, a maioria do cobre ingerido e em excesso, sendo este eliminado pelo fígado de forma a não se tornar toxico. Os mecanismos potenciais para a sua acumulação incluem deficiências metabólicas primarias no metabolismo de Cu hepático, colestase que causa comprometimento da excreção biliar de Cu e hepatite. A incidência de níveis de cobre hepático aumentados e hepatopatia associada ao cobre em cães tem aumentado nos últimos anos. Isto pode dever-se a predisposição genética, aporte dietético excessivo, ou uma combinação destes fatores. Este trabalho pretende estudar a prevalência da hepatopatia associada ao cobre em cães num laboratório de referência em Portugal, utilizando como material de estudo os relatórios de histopatologia de cães submetidos a biopsia por suspeita de hepatopatia. Utilizando a base de dados da DNAtech® entre os anos de 2020 e 2021 foram escolhidas amostras de biopsias hepáticas de cães com hepatopatia para determinar a prevalência de hepatopatias associadas ao cobre em Portugal durante este intervalo de tempo. Para elaborar este relatório, foram analisados um total de 176 relatórios histopatológicos. Destes, apenas 89 foram coradas com rodamina, tendo sido os restantes 87 excluídos. Das amostras coradas, oito (8.9%) revelaram-se rodanina positivas. Embora a maioria dos resultados obtidos no presente estudo vá de encontro a bibliografia existente, observou-se uma prevalência de hepatopatia associada ao cobre superior a descrita por outros autores. Palavras-chave: Hepatopatia associada ao cobre; intoxicação por cobre; cobre; fígado; hepático; rodanina
Copper is a fundamental compound of many enzymes involved in a variety of vital biological processes. Although copper is an intrinsic component of different essential proteins, most copper ingested is in excess, being eliminated by the liver in a way that it does not become toxic. Potential mechanisms for its accumulation include primary metabolic deficiencies in hepatic Cu metabolism, cholestasis that causes impaired biliary Cu excretion and hepatitis. The occurrence of increased hepatic copper levels and copper-associated hepatopathy in dogs has become more prevalent over recent years. This may be attributable to genetic predisposition, excessive dietary intake, or a combination of these factors. This work intends to study the prevalence of copper associated hepatopathy in dogs in a reference laboratory in Portugal, using as study material the histopathology reports of dogs submitted to biopsy for suspected hepatopathy. Resorting to the DNAtechâ database between the years of 2020 and 2021, liver biopsies from dogs with hepatopathies were chosen to determine the prevalence of copperassociated liver disease in Portugal during this time. To elaborate this report, a total of 176 histopathological reports were analyzed. Only 89 were stained with rhodanine, and the remaining 87 were excluded. Of the stained samples, eight samples (8.9%) were rhodanine positive. Although most of the results obtained in the present study are in accordance with the existing literature, a higher prevalence of copper-associated hepatopathy than that described by other authors was observed. Keywords: Copper-associated liver hepatopathy; copper intoxication; copper; liver; hepatic; rhodanine
Copper is a fundamental compound of many enzymes involved in a variety of vital biological processes. Although copper is an intrinsic component of different essential proteins, most copper ingested is in excess, being eliminated by the liver in a way that it does not become toxic. Potential mechanisms for its accumulation include primary metabolic deficiencies in hepatic Cu metabolism, cholestasis that causes impaired biliary Cu excretion and hepatitis. The occurrence of increased hepatic copper levels and copper-associated hepatopathy in dogs has become more prevalent over recent years. This may be attributable to genetic predisposition, excessive dietary intake, or a combination of these factors. This work intends to study the prevalence of copper associated hepatopathy in dogs in a reference laboratory in Portugal, using as study material the histopathology reports of dogs submitted to biopsy for suspected hepatopathy. Resorting to the DNAtechâ database between the years of 2020 and 2021, liver biopsies from dogs with hepatopathies were chosen to determine the prevalence of copperassociated liver disease in Portugal during this time. To elaborate this report, a total of 176 histopathological reports were analyzed. Only 89 were stained with rhodanine, and the remaining 87 were excluded. Of the stained samples, eight samples (8.9%) were rhodanine positive. Although most of the results obtained in the present study are in accordance with the existing literature, a higher prevalence of copper-associated hepatopathy than that described by other authors was observed. Keywords: Copper-associated liver hepatopathy; copper intoxication; copper; liver; hepatic; rhodanine
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Orientação: Pedro Faísca
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VETERINÁRIA, MEDICINA VETERINÁRIA, VETERINARY MEDICINE, CANÍDEOS, CANIDS, CÃES, DOGS, DOENÇAS HEPÁTICAS, HEPATIC DISEASES, INTOXICAÇÃO, INTOXICATION, FÍGADO, LIVER, MESTRADO INTEGRADO EM MEDICINA VETERINÁRIA, COBRE, COPPER